InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SRSF1

Summary

InnateDB Gene

IDBG-60601.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRSF1

Gene Name

serine/arginine-rich splicing factor 1

Synonyms

ASF; SF2; SF2p33; SFRS1; SRp30a

Species

Homo sapiens

Ensembl Gene

ENSG00000136450

Encoded Proteins

IDBP-60605

serine/arginine-rich splicing factor 1

IDBP-760660

IDBP-764155

IDBP-763811

IDBP-764367

IDBP-761800

IDBP-758771

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the arginine/serine-rich splicing factor protein family, and functions in both constitutive and alternative pre-mRNA splicing. The protein binds to pre-mRNA transcripts and components of the spliceosome, and can either activate or repress splicing depending on the location of the pre-mRNA binding site. The protein's ability to activate splicing is regulated by phosphorylation and interactions with other splicing factor associated proteins. Multiple transcript variants encoding different isoforms have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 13. [provided by RefSeq, Sep 2010]
This gene encodes a member of the arginine/serine-rich splicing factor protein family. The encoded protein can either activate or repress splicing, depending on its phosphorylation state and its interaction partners. Multiple transcript variants have been found for this gene. There is a pseudogene of this gene on chromosome 13. [provided by RefSeq, Jun 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:58003360-58007346

Strand

Reverse strand

Band

q22

Transcripts

ENST00000258962	ENSP00000258962
ENST00000578430
ENST00000581497
ENST00000584668	ENSP00000462616
ENST00000582730	ENSP00000462215
ENST00000581979	ENSP00000463223
ENST00000583741	ENSP00000463917
ENST00000585096	ENSP00000462687
ENST00000584773	ENSP00000463042

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 171 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	171 [view]
Protein-Protein	166 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0050733	RS domain binding

Biological Process

GO:0000395	mRNA 5'-splice site recognition
GO:0000398	mRNA splicing, via spliceosome
GO:0001701	in utero embryonic development
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0006376	mRNA splice site selection
GO:0006397	mRNA processing
GO:0006406	mRNA export from nucleus
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0031124	mRNA 3'-end processing
GO:0060048	cardiac muscle contraction

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0016607	nuclear speck
GO:0035145	exon-exon junction complex
GO:0070062	extracellular vesicular exosome
GO:0071013	catalytic step 2 spliceosome