Version 5.4
Bos taurus Gene: GCSH
Summary
InnateDB Gene IDBG-629377.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GCSH
Gene Name Glycine cleavage system H protein, mitochondrial
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000006795
Encoded Proteins
IDBP-680779
Glycine cleavage system H protein, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140905:
Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the H protein, which transfers the methylamine group of glycine from the P protein to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH). Two transcript variants, one protein-coding and the other probably not protein-coding,have been found for this gene. Also, several transcribed and non-transcribed pseudogenes of this gene exist throughout the genome.[provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:7793106-7805806
Strand Reverse strand
Band
Transcripts
ENSBTAT00000008936 ENSBTAP00000008936
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006546 glycine catabolic process
GO:0019464 glycine decarboxylation via glycine cleavage system
Cellular Component
GO:0005739 mitochondrion
GO:0005960 glycine cleavage complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000140905
View Gene Order
ENSMUSG00000034424
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00260
Glycine, serine and threonine metabolism pathway
hsa00630
Glyoxylate and dicarboxylate metabolism pathway
mmu00260
Glycine, serine and threonine metabolism pathway
mmu00630
Glyoxylate and dicarboxylate metabolism pathway
INOH
PID NCI
Cross-References
SwissProt P20821
TrEMBL
UniProt Splice Variant
Entrez Gene 317723
UniGene Bt.67330
RefSeq NM_174844 XM_005198587 XM_005207685
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC120070 M58361
GenPept AAA62710 AAI20071
RNA Seq Atlas 101905887 317723

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca