Version 5.4
Mus musculus Gene: Gcsh
Summary
InnateDB Gene IDBG-194723.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gcsh
Gene Name glycine cleavage system protein H (aminomethyl carrier)
Synonyms 1100001L02Rik; 5730591C18Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000034424
Encoded Proteins
IDBP-194725
glycine cleavage system protein H (aminomethyl carrier)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140905:
Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the H protein, which transfers the methylamine group of glycine from the P protein to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH). Two transcript variants, one protein-coding and the other probably not protein-coding,have been found for this gene. Also, several transcribed and non-transcribed pseudogenes of this gene exist throughout the genome.[provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:116981810-116993537
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000040484 ENSMUSP00000037131
ENSMUST00000162548
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004047 aminomethyltransferase activity
GO:0019899 enzyme binding
Biological Process
GO:0006546 glycine catabolic process
GO:0019464 glycine decarboxylation via glycine cleavage system
GO:0032259 methylation
Cellular Component
GO:0005739 mitochondrion
GO:0005960 glycine cleavage complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000140905
View Gene Order
ENSBTAG00000006795
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00260
Glycine, serine and threonine metabolism pathway
mmu00630
Glyoxylate and dicarboxylate metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00260
Glycine, serine and threonine metabolism pathway
hsa00630
Glyoxylate and dicarboxylate metabolism pathway
INOH
PID NCI
Cross-References
SwissProt Q91WK5
TrEMBL Q9CV53
UniProt Splice Variant
Entrez Gene 68133
UniGene Mm.258462 Mm.436956
RefSeq NM_026572 XM_006543036
OMIM
CCDS CCDS22696
HPRD
IMGT
MGI ID MGI:1915383
MGI Symbol Gcsh
EMBL AC162858 AK003788 AK009543 AK019983 AK050373 BC014745 CH466525
GenPept AAH14745 BAB22996 BAB26349 BAB31951 BAC34217 EDL11574
RNA Seq Atlas 102641654 68133

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca