Version 5.4
Bos taurus Gene: ADCY10
Summary
InnateDB Gene IDBG-629473.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADCY10
Gene Name Uncharacterized protein
Synonyms sAC; SACY
Species Bos taurus
Ensembl Gene ENSBTAG00000001052
Encoded Proteins
IDBP-680943
adenylate cyclase 10 (soluble)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143199:
The protein encoded by this gene belongs to a distinct class of mammalian adenylyl cyclase that is soluble and insensitive to G protein or forskolin regulation. It is thought to function as a general bicarbonate sensor throughout the body. It may also play an important role in the generation of cAMP in spermatozoa, implying possible roles in sperm maturation through the epididymis, capacitation, hypermotility, and/or the acrosome reaction. Genetic variations in this gene are associated with absorptive hypercalciuria type 2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:825294-905484
Strand Forward strand
Band
Transcripts
ENSBTAT00000001400 ENSBTAP00000001400
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004016 adenylate cyclase activity
GO:0005524 ATP binding
GO:0016829 lyase activity
GO:0016849 phosphorus-oxygen lyase activity
Biological Process
GO:0006171 cAMP biosynthetic process
GO:0007283 spermatogenesis
GO:0009190 cyclic nucleotide biosynthetic process
GO:0035556 intracellular signal transduction
Cellular Component
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000143199
View Gene Order
ENSMUSG00000026567
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_228134
Signaling by Hedgehog pathway
REACT_111102
Signal Transduction pathway
REACT_267634
Hedgehog 'off' state pathway
REACT_269412
Hedgehog 'off' state pathway
REACT_250064
Signaling by Hedgehog pathway
REACT_188257
Signal Transduction pathway
KEGG
hsa00230
Purine metabolism pathway
mmu00230
Purine metabolism pathway
INOH
INOH website
GPCR Adenosine A2A receptor signaling pathway pathway
INOH website
Purine nucleotides nucleosides metabolism pathway
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq XM_003581912 XM_003585812 XM_005203412 XM_005203413 XM_005203416 XM_005203417 XM_005203418
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca