InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Adcy10

Summary

InnateDB Gene

IDBG-202672.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adcy10

Gene Name

adenylate cyclase 10

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026567

Encoded Proteins

IDBP-202674

adenylate cyclase 10

IDBP-258098

adenylate cyclase 10

IDBP-258100

adenylate cyclase 10

IDBP-716413

IDBP-715241

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143199:
The protein encoded by this gene belongs to a distinct class of mammalian adenylyl cyclase that is soluble and insensitive to G protein or forskolin regulation. It is thought to function as a general bicarbonate sensor throughout the body. It may also play an important role in the generation of cAMP in spermatozoa, implying possible roles in sperm maturation through the epididymis, capacitation, hypermotility, and/or the acrosome reaction. Genetic variations in this gene are associated with absorptive hypercalciuria type 2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:165485183-165576774

Strand

Forward strand

Band

H2.2

Transcripts

ENSMUST00000027852	ENSMUSP00000027852
ENSMUST00000111440	ENSMUSP00000107067
ENSMUST00000111439	ENSMUSP00000107066
ENSMUST00000148550	ENSMUSP00000137959
ENSMUST00000155216	ENSMUSP00000137744
ENSMUST00000124037

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004016	adenylate cyclase activity
GO:0005524	ATP binding
GO:0016849	phosphorus-oxygen lyase activity
GO:0030145	manganese ion binding
GO:0051117	ATPase binding

Biological Process

GO:0006171	cAMP biosynthetic process
GO:0007283	spermatogenesis
GO:0009190	cyclic nucleotide biosynthetic process
GO:0035556	intracellular signal transduction
GO:0043065	positive regulation of apoptotic process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0030426	growth cone
GO:0043025	neuronal cell body
GO:0045177	apical part of cell
GO:0045178	basal part of cell
GO:0048471	perinuclear region of cytoplasm