Version 5.4
| Bos taurus Gene: ANAPC10 | |||||||||||||
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| Summary | |||||||||||||
| InnateDB Gene | IDBG-629492.3 | ||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
| Gene Symbol | ANAPC10 | ||||||||||||
| Gene Name | anaphase-promoting complex subunit 10 | ||||||||||||
| Synonyms | |||||||||||||
| Species | Bos taurus | ||||||||||||
| Ensembl Gene | ENSBTAG00000013326 | ||||||||||||
| Encoded Proteins |
anaphase-promoting complex subunit 10
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| Protein Structure | |||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
| Entrez Gene | |||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164162:
ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by OMIM, Feb 2011] |
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| Gene Information | |||||||||||||
| Type | Protein coding | ||||||||||||
| Genomic Location | Chromosome 17:13364489-13446148 | ||||||||||||
| Strand | Forward strand | ||||||||||||
| Band | |||||||||||||
| Transcripts |
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| Interactions | |||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||
| NETPATH |
TGF_beta_Receptor pathway
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| REACTOME |
Inactivation of APC/C via direct inhibition of the APC/C complex pathway
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
APC/C:Cdc20 mediated degradation of Cyclin B pathway
APC/C:Cdc20 mediated degradation of Securin pathway
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Phosphorylation of the APC/C pathway
Autodegradation of Cdh1 by Cdh1:APC/C pathway
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
Separation of Sister Chromatids pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Cellular responses to stress pathway
APC/C-mediated degradation of cell cycle proteins pathway
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Regulation of mitotic cell cycle pathway
Cell Cycle pathway
Adaptive Immune System pathway
Mitotic Spindle Checkpoint pathway
Immune System pathway
M Phase pathway
Cellular Senescence pathway
Mitotic Anaphase pathway
Cell Cycle, Mitotic pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Class I MHC mediated antigen processing & presentation pathway
Cell Cycle Checkpoints pathway
Mitotic Metaphase and Anaphase pathway
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway
Cell Cycle, Mitotic pathway
Class I MHC mediated antigen processing & presentation pathway
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Separation of Sister Chromatids pathway
Cellular responses to stress pathway
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Cell Cycle pathway
APC/C-mediated degradation of cell cycle proteins pathway
Immune System pathway
M Phase pathway
Cell Cycle Checkpoints pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Cellular Senescence pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
Autodegradation of Cdh1 by Cdh1:APC/C pathway
Regulation of mitotic cell cycle pathway
APC/C:Cdc20 mediated degradation of Securin pathway
Mitotic Metaphase and Anaphase pathway
Phosphorylation of the APC/C pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Inactivation of APC/C via direct inhibition of the APC/C complex pathway
Adaptive Immune System pathway
Mitotic Spindle Checkpoint pathway
Mitotic Anaphase pathway
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway
APC/C:Cdc20 mediated degradation of Cyclin B pathway
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| KEGG |
Cell cycle pathway
Ubiquitin mediated proteolysis pathway
Progesterone-mediated oocyte maturation pathway
Oocyte meiosis pathway
Ubiquitin mediated proteolysis pathway
Cell cycle pathway
Progesterone-mediated oocyte maturation pathway
Oocyte meiosis pathway
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| INOH | |||||||||||||
| PID NCI | |||||||||||||
| Cross-References | |||||||||||||
| SwissProt | |||||||||||||
| TrEMBL | F2Z4G9 | ||||||||||||
| UniProt Splice Variant | |||||||||||||
| Entrez Gene | 783986 | ||||||||||||
| UniGene | Bt.17077 | ||||||||||||
| RefSeq | NM_001080357 XM_005217512 | ||||||||||||
| HUGO | HGNC:24077 | ||||||||||||
| OMIM | |||||||||||||
| CCDS | |||||||||||||
| HPRD | |||||||||||||
| IMGT | |||||||||||||
| EMBL | DAAA02044342 DAAA02044343 | ||||||||||||
| GenPept | |||||||||||||
| RNA Seq Atlas | 783986 | ||||||||||||