Version 5.4
Homo sapiens Gene: ANAPC10
Summary
InnateDB Gene IDBG-39771.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANAPC10
Gene Name anaphase promoting complex subunit 10
Synonyms APC10; DOC1
Species Homo sapiens
Ensembl Gene ENSG00000164162
Encoded Proteins
IDBP-39773
anaphase promoting complex subunit 10
IDBP-378119
anaphase promoting complex subunit 10
IDBP-479614
anaphase promoting complex subunit 10
IDBP-481984
anaphase promoting complex subunit 10
IDBP-484799
anaphase promoting complex subunit 10
IDBP-473380
anaphase promoting complex subunit 10
IDBP-484597
anaphase promoting complex subunit 10
IDBP-483600
anaphase promoting complex subunit 10
IDBP-811537
anaphase promoting complex subunit 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by OMIM, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:144967112-145098541
Strand Reverse strand
Band q31.21
Transcripts
ENST00000309439 ENSP00000310071
ENST00000451299 ENSP00000403891
ENST00000506851
ENST00000502651
ENST00000507656 ENSP00000423995
ENST00000510270
ENST00000511466
ENST00000514390 ENSP00000423043
ENST00000513054 ENSP00000421609
ENST00000502562
ENST00000512680 ENSP00000425459
ENST00000508087
ENST00000504721 ENSP00000423223
ENST00000514704
ENST00000507134
ENST00000502847 ENSP00000424463
ENST00000613466 ENSP00000478501
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 52 [view]
Protein-Protein 50 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000090 mitotic anaphase
GO:0000278 mitotic cell cycle
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007067 mitotic nuclear division
GO:0007094 mitotic spindle assembly checkpoint
GO:0030071 regulation of mitotic metaphase/anaphase transition
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0070979 protein K11-linked ubiquitination
Cellular Component
GO:0005654 nucleoplasm
GO:0005680 anaphase-promoting complex
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036977
View Gene Order
ENSBTAG00000013326
Not yet available
Pathways
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_1072
Inactivation of APC/C via direct inhibition of the APC/C complex pathway
REACT_1041
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway
REACT_6761
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
REACT_6820
APC/C:Cdc20 mediated degradation of Cyclin B pathway
REACT_6871
APC/C:Cdc20 mediated degradation of Securin pathway
REACT_6781
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_6904
Phosphorylation of the APC/C pathway
REACT_6785
Autodegradation of Cdh1 by Cdh1:APC/C pathway
REACT_6867
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway
REACT_6837
Regulation of APC/C activators between G1/S and early anaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_120956
Cellular responses to stress pathway
REACT_6828
APC/C-mediated degradation of cell cycle proteins pathway
REACT_6954
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_21279
Regulation of mitotic cell cycle pathway
REACT_115566
Cell Cycle pathway
REACT_75774
Adaptive Immune System pathway
REACT_2137
Mitotic Spindle Checkpoint pathway
REACT_6900
Immune System pathway
REACT_910
M Phase pathway
REACT_169274
Cellular Senescence pathway
REACT_1275
Mitotic Anaphase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_169168
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_1538
Cell Cycle Checkpoints pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
hsa04110
Cell cycle pathway
hsa04120
Ubiquitin mediated proteolysis pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa04114
Oocyte meiosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.480876 Hs.686823 Hs.733123
RefSeq NM_001256706 NM_001256707 NM_001256708 NM_001256709 NM_014885 XM_006714058 XM_006714060
HUGO
OMIM
CCDS CCDS43273
HPRD 16488
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca