Version 5.4
Bos taurus Gene: HCN1
Summary
InnateDB Gene IDBG-629533.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HCN1
Gene Name hyperpolarization activated cyclic nucleotide-gated potassium channel 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000043948
Encoded Proteins
IDBP-680938
hyperpolarization activated cyclic nucleotide-gated potassium channel 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164588:
The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:29121455-29566631
Strand Forward strand
Band
Transcripts
ENSBTAT00000061021 ENSBTAP00000053284
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005222 intracellular cAMP activated cation channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005515 protein binding
GO:0030552 cAMP binding
GO:0042802 identical protein binding
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0035725 sodium ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0045176 apical protein localization
GO:0046549 retinal cone cell development
GO:0055085 transmembrane transport
GO:0071320 cellular response to cAMP
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0030425 dendrite
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000164588
View Gene Order
ENSMUSG00000021730
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_13685
Neuronal System pathway
REACT_75862
HCN channels pathway
REACT_75908
Potassium Channels pathway
REACT_202800
Potassium Channels pathway
REACT_259290
Neuronal System pathway
REACT_199079
HCN channels pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BM97
UniProt Splice Variant
Entrez Gene 538255
UniGene Bt.94610
RefSeq NM_001206580
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02050448 DAAA02050449 DAAA02050450 DAAA02050451 DAAA02050452 DAAA02050453 DAAA02050454 DAAA02050455 DAAA02050456 DAAA02050457 DAAA02050458 DAAA02050459
GenPept
RNA Seq Atlas 538255
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca