InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hcn1

Summary

InnateDB Gene

IDBG-184588.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hcn1

Gene Name

hyperpolarization-activated, cyclic nucleotide-gated K+ 1

Synonyms

Bcng1; C630013B14Rik; HAC2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021730

Encoded Proteins

IDBP-184590

hyperpolarization-activated, cyclic nucleotide-gated K+ 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164588:
The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:117602480-117976802

Strand

Forward strand

Band

D2.3

Transcripts

ENSMUST00000006991

ENSMUSP00000006991

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005222	intracellular cAMP activated cation channel activity
GO:0005248	voltage-gated sodium channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005272	sodium channel activity
GO:0005515	protein binding
GO:0030552	cAMP binding
GO:0042802	identical protein binding

Biological Process

GO:0006811	ion transport
GO:0034765	regulation of ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0045176	apical protein localization
GO:0046549	retinal cone cell development
GO:0055085	transmembrane transport
GO:0071320	cellular response to cAMP
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0030424	axon
GO:0030425	dendrite

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000164588

View Gene Order

ENSBTAG00000043948

Not yet available

Pathways

NETPATH

REACTOME

REACT_202800

Potassium Channels pathway

REACT_259290

Neuronal System pathway

REACT_199079

HCN channels pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_13685

Neuronal System pathway

REACT_75862

HCN channels pathway

REACT_75908

Potassium Channels pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

O88704

TrEMBL

UniProt Splice Variant

Entrez Gene

15165

UniGene

Mm.343429

RefSeq

NM_010408 XM_006517529

OMIM

CCDS

CCDS26793

HPRD

IMGT

MGI ID

MGI:1096392

MGI Symbol

Hcn1

EMBL

AF028737 AJ225123 AK014722

GenPept

AAC53518 CAA12407

RNA Seq Atlas

15165