Version 5.4
Bos taurus Gene: MLYCD
Summary
InnateDB Gene IDBG-629691.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MLYCD
Gene Name malonyl-CoA decarboxylase, mitochondrial
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000004248
Encoded Proteins
IDBP-681103
malonyl-CoA decarboxylase, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000103150:
The product of this gene catalyzes the breakdown of malonyl-CoA to acetyl-CoA and carbon dioxide. Malonyl-CoA is an intermediate in fatty acid biosynthesis, and also inhibits the transport of fatty acyl CoAs into mitochondria. Consequently, the encoded protein acts to increase the rate of fatty acid oxidation. It is found in mitochondria, peroxisomes, and the cytoplasm. Mutations in this gene result in malonyl-CoA decarboyxlase deficiency. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:10250180-10263073
Strand Forward strand
Band
Transcripts
ENSBTAT00000005562 ENSBTAP00000005562
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0050080 malonyl-CoA decarboxylase activity
Biological Process
GO:0006633 fatty acid biosynthetic process
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000103150
View Gene Order
ENSMUSG00000074064
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_16957
Peroxisomal lipid metabolism pathway
REACT_111217
Metabolism pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_246750
Peroxisomal lipid metabolism pathway
KEGG
hsa00640
Propanoate metabolism pathway
hsa00410
beta-Alanine metabolism pathway
hsa04146
Peroxisome pathway
mmu00410
beta-Alanine metabolism pathway
mmu00640
Propanoate metabolism pathway
mmu04146
Peroxisome pathway
INOH
INOH website
Pyruvate metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL A5PJC5
UniProt Splice Variant
Entrez Gene 512341
UniGene Bt.46080
RefSeq NM_001098946
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC142049 DAAA02046162
GenPept AAI42050
RNA Seq Atlas 512341

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca