Version 5.4
Homo sapiens Gene: MLYCD
Summary
InnateDB Gene IDBG-43960.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MLYCD
Gene Name malonyl-CoA decarboxylase
Synonyms MCD
Species Homo sapiens
Ensembl Gene ENSG00000103150
Encoded Proteins
IDBP-43962
malonyl-CoA decarboxylase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene catalyzes the breakdown of malonyl-CoA to acetyl-CoA and carbon dioxide. Malonyl-CoA is an intermediate in fatty acid biosynthesis, and also inhibits the transport of fatty acyl CoAs into mitochondria. Consequently, the encoded protein acts to increase the rate of fatty acid oxidation. It is found in mitochondria, peroxisomes, and the cytoplasm. Mutations in this gene result in malonyl-CoA decarboyxlase deficiency. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:83899126-83927026
Strand Forward strand
Band q23.3
Transcripts
ENST00000262430 ENSP00000262430
ENST00000569024
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0050080 malonyl-CoA decarboxylase activity
Biological Process
GO:0002931 response to ischemia
GO:0006085 acetyl-CoA biosynthetic process
GO:0006633 fatty acid biosynthetic process
GO:0010906 regulation of glucose metabolic process
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0046321 positive regulation of fatty acid oxidation
GO:2001294 malonyl-CoA catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000074064
View Gene Order
ENSBTAG00000004248
Not yet available
Pathways
NETPATH
REACTOME
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_16957
Peroxisomal lipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00640
Propanoate metabolism pathway
hsa00410
beta-Alanine metabolism pathway
hsa04146
Peroxisome pathway
INOH
INOH website
Pyruvate metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.644610 Hs.728122
RefSeq NM_012213
HUGO
OMIM
CCDS CCDS42206
HPRD 05999
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca