Version 5.4
Bos taurus Gene: BT.65645
Summary
InnateDB Gene IDBG-629768.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.65645
Gene Name protein SON
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000008482
Encoded Proteins
IDBP-681197
SON DNA-binding protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159140:
The protein encoded by this gene binds to a specific DNA sequence upstream of the upstream regulatory sequence of the core promoter and second enhancer of human hepatitis B virus (HBV). Through this binding, it represses HBV core promoter activity, transcription of HBV genes, and production of HBV virions. The protein shows sequence similarities with other DNA-binding structural proteins such as gallin, oncoproteins of the MYC family, and the oncoprotein MOS. It may also be involved in protecting cells from apoptosis and in pre-mRNA splicing. Several transcript variants encoding different isoforms have been described for this gene, but the full-length nature of only two of them has been determined. [provided by RefSeq, Jul 2008]
This gene encodes a protein that contains multiple simple repeats. The encoded protein binds RNA and promotes pre-mRNA splicing, particularly of transcripts with poor splice sites. The protein also recognizes a specific DNA sequence found in the human hepatitis B virus (HBV) and represses HBV core promoter activity. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:1233910-1264762
Strand Reverse strand
Band
Transcripts
ENSBTAT00000011175 ENSBTAP00000011175
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.
Predicted by orthology
Total 53 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
GO:0050733 RS domain binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0000910 cytokinesis
GO:0006397 mRNA processing
GO:0043066 negative regulation of apoptotic process
GO:0043484 regulation of RNA splicing
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus
GO:0016607 nuclear speck
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000159140
View Gene Order
ENSMUSG00000022961
View Gene Order
Cross-References
SwissProt
TrEMBL F1MYN8
UniProt Splice Variant
Entrez Gene 516462
UniGene Bt.101558 Bt.65645
RefSeq NM_001083694
HUGO HGNC:11183
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02000033
GenPept
RNA Seq Atlas 516462

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca