InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SON

Summary

InnateDB Gene

IDBG-2322.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SON

Gene Name

SON DNA binding protein

Synonyms

BASS1; C21orf50; DBP-5; NREBP; SON3

Species

Homo sapiens

Ensembl Gene

ENSG00000159140

Encoded Proteins

IDBP-2330

SON DNA binding protein

IDBP-2332

SON DNA binding protein

IDBP-2336

SON DNA binding protein

IDBP-2340

SON DNA binding protein

IDBP-363128

SON DNA binding protein

IDBP-363133

SON DNA binding protein

IDBP-363137

SON DNA binding protein

IDBP-363138

SON DNA binding protein

IDBP-363140

SON DNA binding protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene binds to a specific DNA sequence upstream of the upstream regulatory sequence of the core promoter and second enhancer of human hepatitis B virus (HBV). Through this binding, it represses HBV core promoter activity, transcription of HBV genes, and production of HBV virions. The protein shows sequence similarities with other DNA-binding structural proteins such as gallin, oncoproteins of the MYC family, and the oncoprotein MOS. It may also be involved in protecting cells from apoptosis and in pre-mRNA splicing. Several transcript variants encoding different isoforms have been described for this gene, but the full-length nature of only two of them has been determined. [provided by RefSeq, Jul 2008]
This gene encodes a protein that contains multiple simple repeats. The encoded protein binds RNA and promotes pre-mRNA splicing, particularly of transcripts with poor splice sites. The protein also recognizes a specific DNA sequence found in the human hepatitis B virus (HBV) and represses HBV core promoter activity. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:33542618-33577481

Strand

Forward strand

Band

q22.11

Transcripts

ENST00000290239
ENST00000381692	ENSP00000371111
ENST00000356577	ENSP00000348984
ENST00000300278	ENSP00000300278
ENST00000381679	ENSP00000371095
ENST00000455528	ENSP00000399783
ENST00000436227	ENSP00000400985
ENST00000421541	ENSP00000405807
ENST00000429093	ENSP00000401942
ENST00000457208	ENSP00000404135
ENST00000475072
ENST00000492229
ENST00000474355
ENST00000467616
ENST00000484294
ENST00000473102
ENST00000470533
ENST00000478183
ENST00000465834
ENST00000477419
ENST00000491794

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	73 [view]
Protein-Protein	72 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0050733	RS domain binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0000910	cytokinesis
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0043066	negative regulation of apoptotic process
GO:0043484	regulation of RNA splicing
GO:0051726	regulation of cell cycle

Cellular Component

GO:0005634	nucleus
GO:0016607	nuclear speck

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022961

View Gene Order

ENSBTAG00000008482

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

6651

UniGene

Hs.517262 Hs.619650 Hs.656725

RefSeq

NM_001291411 NM_001291412 NM_032195 NM_138927 XM_006724045

HUGO

HGNC:11183

OMIM

182465

CCDS

CCDS13629 CCDS13631 CCDS74784

HPRD

01678

IMGT

EMBL

GenPept

RNA Seq Atlas

6651