InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TOPORS

Summary

InnateDB Gene

IDBG-629770.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TOPORS

Gene Name

E3 ubiquitin-protein ligase Topors

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000005905

Encoded Proteins

IDBP-681184

topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197579:
This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus. [provided by RefSeq, Sep 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:11391203-11401136

Strand

Forward strand

Band

Transcripts

ENSBTAT00000048966

ENSBTAP00000045917

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.

Predicted by orthology
Total	41 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003823	antigen binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019789	SUMO ligase activity
GO:0043015	gamma-tubulin binding
GO:0044547	DNA topoisomerase binding
GO:0046872	metal ion binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006513	protein monoubiquitination
GO:0006974	cellular response to DNA damage stimulus
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0016925	protein sumoylation
GO:0034504	protein localization to nucleus
GO:0042127	regulation of cell proliferation
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051443	positive regulation of ubiquitin-protein transferase activity
GO:0051457	maintenance of protein location in nucleus
GO:0070936	protein K48-linked ubiquitination

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0000922	spindle pole
GO:0000930	gamma-tubulin complex
GO:0005634	nucleus
GO:0005813	centrosome
GO:0005814	centriole
GO:0016605	PML body
GO:0016607	nuclear speck
GO:0032391	photoreceptor connecting cilium
GO:0036064	ciliary basal body

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000197579

View Gene Order

ENSMUSG00000036822

View Gene Order

Cross-References

SwissProt

TrEMBL

F1N329

UniProt Splice Variant

Entrez Gene

523321

UniGene

Bt.56498

RefSeq

NM_001192578 XM_005209853

HUGO

HGNC:21653

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02021989

GenPept

RNA Seq Atlas

523321