InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Topors

Summary

InnateDB Gene

IDBG-136139.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Topors

Gene Name

topoisomerase I binding, arginine/serine-rich

Synonyms

AW105885; LUN; p53BP3/LUN; TP53BPL

Species

Mus musculus

Ensembl Gene

ENSMUSG00000036822

Encoded Proteins

IDBP-136141

topoisomerase I binding, arginine/serine-rich

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197579:
This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus. [provided by RefSeq, Sep 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:40259601-40269850

Strand

Reverse strand

Band

Transcripts

ENSMUST00000042575

ENSMUSP00000046843

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003823	antigen binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019789	SUMO ligase activity
GO:0044547	DNA topoisomerase binding
GO:0046872	metal ion binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006513	protein monoubiquitination
GO:0006974	cellular response to DNA damage stimulus
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0016925	protein sumoylation
GO:0034504	protein localization to nucleus
GO:0042127	regulation of cell proliferation
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051443	positive regulation of ubiquitin-protein transferase activity
GO:0051457	maintenance of protein location in nucleus
GO:0070936	protein K48-linked ubiquitination

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0000922	spindle pole
GO:0000930	gamma-tubulin complex
GO:0005634	nucleus
GO:0005814	centriole
GO:0016605	PML body
GO:0016607	nuclear speck
GO:0032391	photoreceptor connecting cilium
GO:0036064	ciliary basal body

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000197579

View Gene Order

ENSBTAG00000005905

Not yet available

Cross-References

SwissProt

Q80Z37

TrEMBL

UniProt Splice Variant

Entrez Gene

106021

UniGene

Mm.251548 Mm.402043 Mm.481393

RefSeq

NM_134097

OMIM

CCDS

CCDS38710

HPRD

IMGT

MGI ID

MGI:2146189

MGI Symbol

Topors

EMBL

AB072395 AB104865 AK044564 AK134075 AK140250 AK143025 AK153743 BC037141 BC040797

GenPept

AAH37141 AAH40797 BAB69457 BAC31981 BAC65157 BAE22003 BAE24298 BAE25253 BAE32164

RNA Seq Atlas

106021