Bos taurus Gene: COX5B
Summary
InnateDB Gene IDBG-629828.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COX5B
Gene Name Cytochrome c oxidase subunit 5B, mitochondrial
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018542
Encoded Proteins
Cytochrome c oxidase subunit 5B, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] COX5B coordinates with the autophagy pathway to control MAVS aggregation and antiviral signalling.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135940:
Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Vb of the human mitochondrial respiratory chain enzyme. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:2916017-2918064
Strand Reverse strand
Band
Transcripts
ENSBTAT00000024678 ENSBTAP00000024678
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004129 cytochrome-c oxidase activity
GO:0046872 metal ion binding
Biological Process
GO:1902600 hydrogen ion transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005740 mitochondrial envelope
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0045277 respiratory chain complex IV
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathways
NETPATH
REACTOME
Orphan transporters pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Transmembrane transport of small molecules pathway
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
Metabolism pathway
Respiratory electron transport pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
AndrogenReceptor pathway
REACTOME
Respiratory electron transport pathway
Transmembrane transport of small molecules pathway
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
Orphan transporters pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
KEGG
Alzheimer's disease pathway
Oxidative phosphorylation pathway
Parkinson's disease pathway
Huntington's disease pathway
Cardiac muscle contraction pathway
Oxidative phosphorylation pathway
Alzheimer's disease pathway
Parkinson's disease pathway
Cardiac muscle contraction pathway
Huntington's disease pathway
INOH
PID NCI
Cross-References
SwissProt P00428
TrEMBL
UniProt Splice Variant
Entrez Gene 287012
UniGene
RefSeq NM_001034046
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102579 BC147855 M19962
GenPept AAA30465 AAI02580 AAI47856
RNA Seq Atlas 287012