Version 5.4
Bos taurus Gene: POLB
Summary
InnateDB Gene IDBG-629853.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLB
Gene Name DNA polymerase beta
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000000225
Encoded Proteins
IDBP-681276
DNA polymerase beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000070501:
The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 27:36877980-36902798
Strand Forward strand
Band
Transcripts
ENSBTAT00000000276 ENSBTAP00000000276
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0016740 transferase activity
GO:0016779 nucleotidyltransferase activity
GO:0016829 lyase activity
GO:0019899 enzyme binding
GO:0034061 DNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-dependent DNA replication
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006974 cellular response to DNA damage stimulus
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0051402 neuron apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0005876 spindle microtubule
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000070501
View Gene Order
ENSMUSG00000031536
View Gene Order
Pathways
NETPATH
REACTOME
REACT_204980
Resolution of Abasic Sites (AP sites) pathway
REACT_204262
DNA Repair pathway
REACT_227100
Removal of DNA patch containing abasic residue pathway
REACT_202612
Base Excision Repair pathway
REACT_206866
Resolution of AP sites via the single-nucleotide replacement pathway pathway
REACT_218762
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway pathway
REACT_218453
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1357
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway pathway
REACT_933
Resolution of AP sites via the single-nucleotide replacement pathway pathway
REACT_2192
Removal of DNA patch containing abasic residue pathway
REACT_1128
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
REACT_1893
Resolution of Abasic Sites (AP sites) pathway
REACT_1104
Base Excision Repair pathway
REACT_216
DNA Repair pathway
REACT_219627
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway pathway
REACT_231541
Resolution of AP sites via the single-nucleotide replacement pathway pathway
REACT_245705
Base Excision Repair pathway
REACT_227394
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
REACT_233397
DNA Repair pathway
REACT_219337
Removal of DNA patch containing abasic residue pathway
REACT_250836
Resolution of Abasic Sites (AP sites) pathway
KEGG
hsa03410
Base excision repair pathway
mmu03410
Base excision repair pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.19548
RefSeq NM_001034764
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca