Bos taurus Gene: MYO6
Summary
InnateDB Gene IDBG-629903.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYO6
Gene Name myosin-VI
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000016751
Encoded Proteins
myosin VI
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196586:
This gene encodes a protein involved intracellular vesicle and organelle transport, especially in the hair cell of the inner ear. Mutations in this gene have been found in patients with non-syndromic autosomal dominant and recessive hearing loss. [provided by RefSeq, Jul 2008]
This gene encodes a reverse-direction motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The protein consists of a motor domain containing an ATP- and an actin-binding site and a globular tail which interacts with other proteins. This protein maintains the structural integrity of inner ear hair cells and mutations in this gene cause non-syndromic autosomal dominant and recessive hearing loss. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:15670077-15763485
Strand Forward strand
Band
Transcripts
ENSBTAT00000022276 ENSBTAP00000022276
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.
Predicted by orthology
Total 37 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003774 motor activity
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0006605 protein targeting
GO:0006897 endocytosis
GO:0007268 synaptic transmission
GO:0007416 synapse assembly
GO:0007605 sensory perception of sound
GO:0007626 locomotory behavior
GO:0008152 metabolic process
GO:0014047 glutamate secretion
GO:0016358 dendrite development
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0042472 inner ear morphogenesis
GO:0042491 auditory receptor cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048167 regulation of synaptic plasticity
GO:0048839 inner ear development
GO:0051046 regulation of secretion
GO:0071257 cellular response to electrical stimulus
Cellular Component
GO:0001726 ruffle
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0012506 vesicle membrane
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0016459 myosin complex
GO:0016591 DNA-directed RNA polymerase II, holoenzyme
GO:0030424 axon
GO:0031941 filamentous actin
GO:0031965 nuclear membrane
GO:0043025 neuronal cell body
GO:0045334 clathrin-coated endocytic vesicle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
REACTOME
Trafficking of AMPA receptors pathway
Gap junction degradation pathway
Neuronal System pathway
Gap junction trafficking pathway
Transmission across Chemical Synapses pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
Gap junction trafficking and regulation pathway
Membrane Trafficking pathway
KEGG
INOH
PID NCI
Stabilization and expansion of the E-cadherin adherens junction
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.108795
RefSeq XM_005210674 XM_005210675
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas