InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Myo6

Summary

InnateDB Gene

IDBG-187852.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myo6

Gene Name

myosin VI

Synonyms

BC029719; sv; Tlc

Species

Mus musculus

Ensembl Gene

ENSMUSG00000033577

Encoded Proteins

IDBP-187856

myosin VI

IDBP-187858

myosin VI

IDBP-254219

myosin VI

IDBP-254221

myosin VI

IDBP-790026

myosin VI

IDBP-790024

myosin VI

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196586:
This gene encodes a protein involved intracellular vesicle and organelle transport, especially in the hair cell of the inner ear. Mutations in this gene have been found in patients with non-syndromic autosomal dominant and recessive hearing loss. [provided by RefSeq, Jul 2008]
This gene encodes a reverse-direction motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The protein consists of a motor domain containing an ATP- and an actin-binding site and a globular tail which interacts with other proteins. This protein maintains the structural integrity of inner ear hair cells and mutations in this gene cause non-syndromic autosomal dominant and recessive hearing loss. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:80165031-80311729

Strand

Forward strand

Band

Transcripts

ENSMUST00000035889	ENSMUSP00000036181
ENSMUST00000076140	ENSMUSP00000075501
ENSMUST00000113268	ENSMUSP00000108893
ENSMUST00000113266	ENSMUSP00000108891
ENSMUST00000130496
ENSMUST00000156199
ENSMUST00000139981
ENSMUST00000127779	ENSMUSP00000139228
ENSMUST00000143804
ENSMUST00000138650
ENSMUST00000183377
ENSMUST00000184480	ENSMUSP00000139019

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0051015	actin filament binding

Biological Process

GO:0006605	protein targeting
GO:0006897	endocytosis
GO:0007268	synaptic transmission
GO:0007416	synapse assembly
GO:0007605	sensory perception of sound
GO:0007626	locomotory behavior
GO:0008152	metabolic process
GO:0014047	glutamate secretion
GO:0016358	dendrite development
GO:0030330	DNA damage response, signal transduction by p53 class mediator
GO:0042472	inner ear morphogenesis
GO:0042491	auditory receptor cell differentiation
GO:0042493	response to drug
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048167	regulation of synaptic plasticity
GO:0048839	inner ear development
GO:0051046	regulation of secretion
GO:0071257	cellular response to electrical stimulus

Cellular Component

GO:0001726	ruffle
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005902	microvillus
GO:0012506	vesicle membrane
GO:0016020	membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0016459	myosin complex
GO:0016591	DNA-directed RNA polymerase II, holoenzyme
GO:0030139	endocytic vesicle
GO:0030424	axon
GO:0031941	filamentous actin
GO:0031965	nuclear membrane
GO:0032587	ruffle membrane
GO:0043025	neuronal cell body
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex
GO:0045177	apical part of cell
GO:0045202	synapse
GO:0045334	clathrin-coated endocytic vesicle
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome