InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TEK

Summary

InnateDB Gene

IDBG-629912.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TEK

Gene Name

Angiopoietin-1 receptor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020148

Encoded Proteins

IDBP-681342

Angiopoietin-1 receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120156:
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. [provided by RefSeq, Jul 2008]
This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:17040335-17143857

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000026836

ENSBTAP00000026836

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001525	angiogenesis
GO:0001934	positive regulation of protein phosphorylation
GO:0001935	endothelial cell proliferation
GO:0002040	sprouting angiogenesis
GO:0006468	protein phosphorylation
GO:0007160	cell-matrix adhesion
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007507	heart development
GO:0010595	positive regulation of endothelial cell migration
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016310	phosphorylation
GO:0016337	single organismal cell-cell adhesion
GO:0016525	negative regulation of angiogenesis
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030097	hemopoiesis
GO:0030334	regulation of cell migration
GO:0032878	regulation of establishment or maintenance of cell polarity
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0034446	substrate adhesion-dependent cell spreading
GO:0043066	negative regulation of apoptotic process
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0045765	regulation of angiogenesis
GO:0045766	positive regulation of angiogenesis
GO:0045785	positive regulation of cell adhesion
GO:0046777	protein autophosphorylation
GO:0048014	Tie signaling pathway
GO:0051259	protein oligomerization
GO:0051894	positive regulation of focal adhesion assembly
GO:0051897	positive regulation of protein kinase B signaling
GO:0060347	heart trabecula formation
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:1902533	positive regulation of intracellular signal transduction
GO:2000251	positive regulation of actin cytoskeleton reorganization
GO:2000352	negative regulation of endothelial cell apoptotic process

Cellular Component

GO:0001725	stress fiber
GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005884	actin filament
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005902	microvillus
GO:0005911	cell-cell junction
GO:0005925	focal adhesion
GO:0009925	basal plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0030054	cell junction
GO:0045121	membrane raft