InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tek

Summary

InnateDB Gene

IDBG-163684.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tek

Gene Name

endothelial-specific receptor tyrosine kinase

Synonyms

AA517024; Cd202b; Hyk; STK1; Tie-2; Tie2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000006386

Encoded Proteins

IDBP-163686

endothelial-specific receptor tyrosine kinase

IDBP-163688

endothelial-specific receptor tyrosine kinase

IDBP-163690

endothelial-specific receptor tyrosine kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120156:
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. [provided by RefSeq, Jul 2008]
This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:94739289-94874976

Strand

Forward strand

Band

Transcripts

ENSMUST00000073939	ENSMUSP00000073595
ENSMUST00000071168	ENSMUSP00000071162
ENSMUST00000102798	ENSMUSP00000099862
ENSMUST00000131958

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	21 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019838	growth factor binding

Biological Process

GO:0001525	angiogenesis
GO:0001569	patterning of blood vessels
GO:0001570	vasculogenesis
GO:0001666	response to hypoxia
GO:0001934	positive regulation of protein phosphorylation
GO:0001935	endothelial cell proliferation
GO:0001936	regulation of endothelial cell proliferation
GO:0001958	endochondral ossification
GO:0002040	sprouting angiogenesis
GO:0006468	protein phosphorylation
GO:0007160	cell-matrix adhesion
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007507	heart development
GO:0010033	response to organic substance
GO:0010595	positive regulation of endothelial cell migration
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016337	single organismal cell-cell adhesion
GO:0016525	negative regulation of angiogenesis
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030097	hemopoiesis
GO:0030334	regulation of cell migration
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031100	organ regeneration
GO:0032526	response to retinoic acid
GO:0032878	regulation of establishment or maintenance of cell polarity
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0034446	substrate adhesion-dependent cell spreading
GO:0035556	intracellular signal transduction
GO:0043066	negative regulation of apoptotic process
GO:0043434	response to peptide hormone
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0043627	response to estrogen
GO:0045765	regulation of angiogenesis
GO:0045766	positive regulation of angiogenesis
GO:0045785	positive regulation of cell adhesion
GO:0046777	protein autophosphorylation
GO:0048014	Tie signaling pathway
GO:0051259	protein oligomerization
GO:0051591	response to cAMP
GO:0051894	positive regulation of focal adhesion assembly
GO:0051897	positive regulation of protein kinase B signaling
GO:0060347	heart trabecula formation
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:1902533	positive regulation of intracellular signal transduction
GO:2000251	positive regulation of actin cytoskeleton reorganization
GO:2000352	negative regulation of endothelial cell apoptotic process

Cellular Component

GO:0001725	stress fiber
GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005884	actin filament
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005902	microvillus
GO:0005911	cell-cell junction
GO:0005925	focal adhesion
GO:0009925	basal plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0045121	membrane raft