Version 5.4
Bos taurus Gene: EPRS
Summary
InnateDB Gene IDBG-629919.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EPRS
Gene Name glutamyl-prolyl-tRNA synthetase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000006898
Encoded Proteins
IDBP-681499
glutamyl-prolyl-tRNA synthetase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136628:
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a multifunctional aminoacyl-tRNA synthetase that catalyzes the aminoacylation of glutamic acid and proline tRNA species. Alternative splicing has been observed for this gene, but the full-length nature and biological validity of the variant have not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:24171351-24236353
Strand Reverse strand
Band
Transcripts
ENSBTAT00000009064 ENSBTAP00000009064
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.
Predicted by orthology
Total 60 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004818 glutamate-tRNA ligase activity
GO:0004827 proline-tRNA ligase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds
GO:0035613 RNA stem-loop binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006424 glutamyl-tRNA aminoacylation
GO:0006433 prolyl-tRNA aminoacylation
GO:0017148 negative regulation of translation
GO:0043039 tRNA aminoacylation
GO:0071346 cellular response to interferon-gamma
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
GO:0097452 GAIT complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000136628
View Gene Order
ENSMUSG00000026615
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_11
TCR pathway
NetPath_24
TSLP pathway
REACTOME
REACT_15306
Cytosolic tRNA aminoacylation pathway
REACT_15482
tRNA Aminoacylation pathway
REACT_71
Gene Expression pathway
KEGG
hsa00970
Aminoacyl-tRNA biosynthesis pathway
hsa00860
Porphyrin and chlorophyll metabolism pathway
mmu00970
Aminoacyl-tRNA biosynthesis pathway
mmu00860
Porphyrin and chlorophyll metabolism pathway
INOH
INOH website
Glutamate Glutamine metabolism pathway
INOH website
Arginine Proline metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL G3X6L9
UniProt Splice Variant
Entrez Gene 538357
UniGene Bt.24194
RefSeq NM_001243320
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02042556 DAAA02042557 DAAA02042558
GenPept
RNA Seq Atlas 538357

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca