InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: EPRS

Summary

InnateDB Protein

IDBP-681499.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPRS

Protein Name

glutamyl-prolyl-tRNA synthetase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000009064

InnateDB Gene

IDBG-629919 (EPRS)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.

Predicted by orthology
Total	60 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004812	aminoacyl-tRNA ligase activity
GO:0004818	glutamate-tRNA ligase activity
GO:0004827	proline-tRNA ligase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016874	ligase activity
GO:0016876	ligase activity, forming aminoacyl-tRNA and related compounds
GO:0035613	RNA stem-loop binding

Biological Process

GO:0006412	translation
GO:0006418	tRNA aminoacylation for protein translation
GO:0006424	glutamyl-tRNA aminoacylation
GO:0006433	prolyl-tRNA aminoacylation
GO:0017148	negative regulation of translation
GO:0043039	tRNA aminoacylation
GO:0071346	cellular response to interferon-gamma

Cellular Component

GO:0005737	cytoplasm
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0097452	GAIT complex

Protein Structure and Domains

PDB ID

InterPro

IPR000738 WHEP-TRS
IPR000924 Glutamyl/glutaminyl-tRNA synthetase
IPR002314 Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain
IPR002316 Proline-tRNA ligase, class IIa
IPR004154 Anticodon-binding
IPR004499 Proline-tRNA ligase, class IIa, archaeal-type
IPR004526 Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic
IPR006195 Aminoacyl-tRNA synthetase, class II
IPR009068 S15/NS1, RNA-binding
IPR010987 Glutathione S-transferase, C-terminal-like
IPR011035 Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain
IPR016061 Proline-tRNA ligase, class II, C-terminal
IPR017449 Prolyl-tRNA synthetase, class II
IPR020058 Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain
IPR020059 Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain

PFAM

PF00458
PF00587
PF03129
PF09180
PF00749
PF03950

PRINTS

PR00987
PR01046

PIRSF

SMART

SM00991
SM00946

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt