Version 5.4
| Homo sapiens Gene: DEFB103B | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-6300.5 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | DEFB103B | ||||||||||||||||||
| Gene Name | defensin, beta 103B | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000177243 | ||||||||||||||||||
| Encoded Proteins |
defensin, beta 103B
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||
| Summary |
DEFB103A inhibits cell wall biosynthesis in staphylococci by inhibiting those enzymes which use the bactoprenol bound cell wall building block Lipid II as substrate.
DEFB103A is a beta-defensin with direct antimicrobial properties that contribute to local innate immune responses and it aids in combating microbial invasion by being chemotactic for a broad spectrum of leukocytes in a CCR6- and CCR2-dependent manner.
DEFB103A expression is inhibited in human epidermal keratinocytes under high glucose conditions, which in turn contributed to the frequent occurrences of infection associated with diabetic wounds.
DEFB103A (hBD-3) is sequestered by extracellular DNA in Haemophilus influenzae biofilms to reduce its antimicrobial activity.
DEFB103A (hBD3) induces dendritic cell activation, migration and polarization in the skin.
DEFB103A (hBD3) is induced in leprosy type 1 reactions in keratinocytes.
DEFB103A and RNASE7 are induced in human umbilical endothelial cells (HUVECs) by classical inflammatory cytokines such as: IFNG, IL1B and TNF.
Exposure to ambient air pollution particulate matter deregulates the ability of the human type II alveolar epithelial cells (A549) to express the antimicrobial peptides HBD-2 (DEFB4A/DEFB4B) and HBD-3 (DEFB103A/DEFB103B) upon infection with Mycobacterium tuberculosis and increases intracellular M. tuberculosis growth.
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| Entrez Gene | |||||||||||||||||||
| Summary |
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 103B, which has broad spectrum antimicrobial activity and may play an important role in innate epithelial defense. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 8:7428888-7430348 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | p23.1 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Beta defensins pathway
Defensins pathway
Innate Immune System pathway
Immune System pathway
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| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | P81534 | ||||||||||||||||||
| TrEMBL | Q5U7J2 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 55894 | ||||||||||||||||||
| UniGene | Hs.283082 Hs.637221 | ||||||||||||||||||
| RefSeq | NM_018661 | ||||||||||||||||||
| HUGO | HGNC:31702 | ||||||||||||||||||
| OMIM | 606611 | ||||||||||||||||||
| CCDS | CCDS34810 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AB037972 AF217245 AF295370 AF301470 AF516673 AJ237673 AY785153 | ||||||||||||||||||
| GenPept | AAF73853 AAG02237 AAG22030 AAM62424 AAV41025 BAB40572 CAC03097 | ||||||||||||||||||
| RNA Seq Atlas | 414325 55894 | ||||||||||||||||||