InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DEFB103B

Summary

InnateDB Protein

IDBP-6302.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DEFB103B

Protein Name

defensin, beta 103B

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000324633

InnateDB Gene

IDBG-6300 (DEFB103B)

Protein Structure

UniProt Annotation

Function

Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed. {ECO:0000269PubMed:11085990}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Highly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. Low expression in salivary gland, bone marrow, colon, stomach, polyp and larynx. No expression in small intestine. {ECO:0000269PubMed:11085990}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0006952	defense response
GO:0006965	positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
GO:0042742	defense response to bacterium
GO:0045087	innate immune response (InnateDB)