Version 5.4
Bos taurus Gene: IRAK1BP1
Summary
InnateDB Gene IDBG-630000.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IRAK1BP1
Gene Name interleukin-1 receptor-associated kinase 1-binding protein 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000020825
Encoded Proteins
IDBP-681433
interleukin-1 receptor-associated kinase 1 binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 20534545
[Homo sapiens] IRAK1BP1 down-regulates Toll-like receptor-mediated transcription of several pro-inflammatory cytokines by changing the transcriptional profile of activated cells, leading to an increase in IL-10 production and promoting LPS tolerance.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000146243:
Gene Information
Type Protein coding
Genomic Location Chromosome 9:18690420-18703194
Strand Forward strand
Band
Transcripts
ENSBTAT00000027750 ENSBTAP00000027750
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007249 I-kappaB kinase/NF-kappaB signaling
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000146243
View Gene Order
ENSMUSG00000032251
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A8NIA8
UniProt Splice Variant
Entrez Gene 782235
UniGene Bt.19782
RefSeq NM_001110093 XM_005210688
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC109685 DAAA02025389 DAAA02025390
GenPept AAI09686
RNA Seq Atlas 782235

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca