Version 5.4
Mus musculus Gene: Irak1bp1
Summary
InnateDB Gene IDBG-188214.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Irak1bp1
Gene Name interleukin-1 receptor-associated kinase 1 binding protein 1
Synonyms 4921528N06Rik; Aabp3; AI851240; Aip70; Simpl
Species Mus musculus
Ensembl Gene ENSMUSG00000032251
Encoded Proteins
IDBP-188216
interleukin-1 receptor-associated kinase 1 binding protein 1
IDBP-254299
interleukin-1 receptor-associated kinase 1 binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 20534545
[Homo sapiens] IRAK1BP1 down-regulates Toll-like receptor-mediated transcription of several pro-inflammatory cytokines by changing the transcriptional profile of activated cells, leading to an increase in IL-10 production and promoting LPS tolerance.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000146243:
Gene Information
Type Protein coding
Genomic Location Chromosome 9:82829540-82847687
Strand Forward strand
Band E2
Transcripts
ENSMUST00000034783 ENSMUSP00000034783
ENSMUST00000113245 ENSMUSP00000108871
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016301 kinase activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0016310 phosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000146243
View Gene Order
ENSBTAG00000020825
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9ESJ7
TrEMBL G5E885
UniProt Splice Variant
Entrez Gene 65099
UniGene Mm.41415
RefSeq NM_001168240 NM_022986
OMIM
CCDS CCDS23372 CCDS52871
HPRD
IMGT
MGI ID MGI:1929475
MGI Symbol Irak1bp1
EMBL AC132323 AC151966 AF093135 AJ242722 AK009948 AK013036 AK020170 AK020448 AK045436 AK076594 BC061099 CH466522
GenPept AAG16774 AAH61099 BAB26602 BAB32019 BAB32106 BAC25386 BAC32366 BAC36407 CAB92240 EDL26449
RNA Seq Atlas 65099

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca