Version 5.4
Bos taurus Gene: PHIP
Summary
InnateDB Gene IDBG-630005.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PHIP
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000024688
Encoded Proteins
IDBP-681486
pleckstrin homology domain interacting protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000146247:
PHIP binds the pleckstrin homology (PH) domain of insulin receptor substrate-1 (IRS1; MIM 147545), modulates insulin signaling, and plays a role in pancreatic beta cell growth and survival (Farhang-Fallah et al., 2000 [PubMed 11018022]; Podcheko et al., 2007 [PubMed 17636024]).[supplied by OMIM, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:18745213-18852721
Strand Reverse strand
Band
Transcripts
ENSBTAT00000034372 ENSBTAP00000034268
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005158 insulin receptor binding
GO:0005515 protein binding
GO:0070577 lysine-acetylated histone binding
Biological Process
GO:0006606 protein import into nucleus
GO:0007010 cytoskeleton organization
GO:0008284 positive regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0022604 regulation of cell morphogenesis
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0040008 regulation of growth
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000146247
View Gene Order
ENSMUSG00000032253
View Gene Order
Cross-References
SwissProt
TrEMBL F1MPF7
UniProt Splice Variant
Entrez Gene 523186
UniGene Bt.109693
RefSeq XM_002690042 XM_601481
HUGO HGNC:15673
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02025391
GenPept
RNA Seq Atlas 523186

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca