Version 5.4
Homo sapiens Gene: PHIP
Summary
InnateDB Gene IDBG-93358.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PHIP
Gene Name pleckstrin homology domain interacting protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000146247
Encoded Proteins
IDBP-93360
pleckstrin homology domain interacting protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary PHIP binds the pleckstrin homology (PH) domain of insulin receptor substrate-1 (IRS1; MIM 147545), modulates insulin signaling, and plays a role in pancreatic beta cell growth and survival (Farhang-Fallah et al., 2000 [PubMed 11018022]; Podcheko et al., 2007 [PubMed 17636024]).[supplied by OMIM, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:78935867-79078236
Strand Reverse strand
Band q14.1
Transcripts
ENST00000275034 ENSP00000275034
ENST00000479165
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005158 insulin receptor binding
GO:0005515 protein binding
GO:0070577 lysine-acetylated histone binding
Biological Process
GO:0001932 regulation of protein phosphorylation
GO:0006606 protein import into nucleus
GO:0007010 cytoskeleton organization
GO:0008284 positive regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0022604 regulation of cell morphogenesis
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0040008 regulation of growth
GO:0043066 negative regulation of apoptotic process
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway
GO:0045840 positive regulation of mitosis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032253
View Gene Order
ENSBTAG00000024688
Not yet available
Cross-References
SwissProt Q8WWQ0
TrEMBL
UniProt Splice Variant
Entrez Gene 55023
UniGene Hs.511817
RefSeq NM_017934 XM_005248729
HUGO HGNC:15673
OMIM 612870
CCDS CCDS4987
HPRD 10152
IMGT
EMBL AF310250 AJ303102 AK057039 AK075124 AL161957 AL356776 AL450327 BC008909 BC021905 BC081569 BC137488 CH471051 DQ924532
GenPept AAG45145 AAH08909 AAH21905 AAH81569 AAI37489 ABK76299 BAB71353 BAC11417 CAC83118 CAH10776 CAH70884 CAI14406 EAW48718
RNA Seq Atlas 55023

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca