Version 5.4
Bos taurus Gene: OSBPL8
Summary
InnateDB Gene IDBG-630014.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OSBPL8
Gene Name Oxysterol-binding protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000004427
Encoded Proteins
IDBP-681527
oxysterol binding protein-like 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000091039:
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:5823987-5903115
Strand Reverse strand
Band
Transcripts
ENSBTAT00000005804 ENSBTAP00000005804
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015485 cholesterol binding
Biological Process
GO:0006810 transport
GO:0006869 lipid transport
GO:0010891 negative regulation of sequestering of triglyceride
GO:0030336 negative regulation of cell migration
GO:0045444 fat cell differentiation
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0051897 positive regulation of protein kinase B signaling
GO:0090204 protein localization to nuclear pore
Cellular Component
GO:0016020 membrane
GO:0031965 nuclear membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000091039
View Gene Order
ENSMUSG00000020189
View Gene Order
Cross-References
SwissProt
TrEMBL E1BA05
UniProt Splice Variant
Entrez Gene 533350
UniGene Bt.110962
RefSeq XM_002687171 XM_002704211 XM_003586033 XM_005206021 XM_005206022 XM_005206023 XM_005206024
HUGO HGNC:16396
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02012372 DAAA02012373
GenPept
RNA Seq Atlas 533350

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca