Version 5.4
Homo sapiens Gene: OSBPL8
Summary
InnateDB Gene IDBG-48994.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OSBPL8
Gene Name oxysterol binding protein-like 8
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000091039
Encoded Proteins
IDBP-48996
oxysterol binding protein-like 8
IDBP-243977
oxysterol binding protein-like 8
IDBP-243979
oxysterol binding protein-like 8
IDBP-589714
oxysterol binding protein-like 8
IDBP-590472
oxysterol binding protein-like 8
IDBP-594184
oxysterol binding protein-like 8
IDBP-603882
oxysterol binding protein-like 8
IDBP-588820
oxysterol binding protein-like 8
IDBP-592635
oxysterol binding protein-like 8
IDBP-601951
oxysterol binding protein-like 8
IDBP-583258
oxysterol binding protein-like 8
IDBP-583948
oxysterol binding protein-like 8
IDBP-813584
oxysterol binding protein-like 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:76351797-76559809
Strand Reverse strand
Band q21.2
Transcripts
ENST00000261183 ENSP00000261183
ENST00000393250 ENSP00000376940
ENST00000393249 ENSP00000376939
ENST00000548485
ENST00000547540 ENSP00000450238
ENST00000546946 ENSP00000447893
ENST00000552586
ENST00000548535
ENST00000550865
ENST00000548341 ENSP00000446886
ENST00000553139 ENSP00000449618
ENST00000549570 ENSP00000449919
ENST00000550628 ENSP00000447483
ENST00000549646 ENSP00000448394
ENST00000551927 ENSP00000447744
ENST00000547544 ENSP00000447235
ENST00000552178
ENST00000611266 ENSP00000478240
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015485 cholesterol binding
Biological Process
GO:0006869 lipid transport
GO:0010891 negative regulation of sequestering of triglyceride
GO:0030336 negative regulation of cell migration
GO:0045444 fat cell differentiation
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0051897 positive regulation of protein kinase B signaling
GO:0090204 protein localization to nuclear pore
Cellular Component
GO:0016020 membrane
GO:0031965 nuclear membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020189
View Gene Order
ENSBTAG00000004427
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.430849 Hs.605107 Hs.703493 Hs.734733
RefSeq NM_001003712 NM_020841 XM_005268621 XM_005268622 XM_005268623 XM_006719222 XM_006719223 XM_006719224
HUGO
OMIM
CCDS CCDS31862 CCDS41814
HPRD 09478
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca