Version 5.4
Bos taurus Gene: TBX4
Summary
InnateDB Gene IDBG-630031.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TBX4
Gene Name T-box transcription factor TBX4
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000009968
Encoded Proteins
IDBP-681466
T-box 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121075:
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human homolog of mouse Tbx4, which is closely linked to Tbx2 on mouse chromosome 11. Similarly this gene, like TBX2, maps to human chromosome 17. Expression studies in mouse and chicken show that Tbx4 is expressed in developing hindlimb, but not in forelimb buds, suggesting a role for this gene in regulating limb development and specification of limb identity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:11865527-11891936
Strand Reverse strand
Band
Transcripts
ENSBTAT00000013147 ENSBTAP00000013147
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0001525 angiogenesis
GO:0002009 morphogenesis of an epithelium
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0030324 lung development
GO:0030326 embryonic limb morphogenesis
GO:0035108 limb morphogenesis
GO:0048705 skeletal system morphogenesis
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000121075
View Gene Order
ENSMUSG00000000094
View Gene Order
Cross-References
SwissProt
TrEMBL F1MTT6
UniProt Splice Variant
Entrez Gene 508750
UniGene Bt.48002
RefSeq NM_001192193 XM_005219965 XM_005219966 XM_005219967 XM_005219968 XM_005219969 XM_005219970
HUGO HGNC:11603
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02048372
GenPept
RNA Seq Atlas 508750

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca