Version 5.4
Mus musculus Gene: Tbx4
Summary
InnateDB Gene IDBG-206728.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tbx4
Gene Name T-box 4
Synonyms 3930401C23
Species Mus musculus
Ensembl Gene ENSMUSG00000000094
Encoded Proteins
IDBP-206730
T-box 4
IDBP-265360
T-box 4
IDBP-265362
T-box 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121075:
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human homolog of mouse Tbx4, which is closely linked to Tbx2 on mouse chromosome 11. Similarly this gene, like TBX2, maps to human chromosome 17. Expression studies in mouse and chicken show that Tbx4 is expressed in developing hindlimb, but not in forelimb buds, suggesting a role for this gene in regulating limb development and specification of limb identity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:85886422-85916097
Strand Forward strand
Band C
Transcripts
ENSMUST00000000096 ENSMUSP00000000096
ENSMUST00000108047 ENSMUSP00000103682
ENSMUST00000108045 ENSMUSP00000103680
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0001525 angiogenesis
GO:0002009 morphogenesis of an epithelium
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0030324 lung development
GO:0030326 embryonic limb morphogenesis
GO:0035108 limb morphogenesis
GO:0048705 skeletal system morphogenesis
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000121075
View Gene Order
ENSBTAG00000009968
Not yet available
Cross-References
SwissProt P70325
TrEMBL Q8BSY3
UniProt Splice Variant
Entrez Gene 21387
UniGene Mm.275336
RefSeq XM_006532779 XM_006532780 NM_011536 NM_172798 XM_006532781
OMIM
CCDS CCDS25196 CCDS48874
HPRD
IMGT
MGI ID MGI:102556
MGI Symbol Tbx4
EMBL AK028407 AK147984 AL592465 AY075134 CH466556 U57329
GenPept AAC53108 AAL77209 BAC25935 BAE28267 CAI25365 EDL15777
RNA Seq Atlas 21387

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca