Version 5.4
Bos taurus Gene: PLA2G12B
Summary
InnateDB Gene IDBG-630038.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLA2G12B
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000009350
Encoded Proteins
IDBP-681480
phospholipase A2, group XIIB
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138308:
Phospholipase A2 (PLA2) enzymes catalyze hydrolysis of glycolipids to release free fatty acids and lysophospholipids. PLA2G12B belongs to the PLA2 family, but it is catalytically inactive due to an amino acid change in its active site and has altered phospholipid-binding properties (Rouault et al., 2003 [PubMed 14516201]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 28:29106433-29125279
Strand Reverse strand
Band
Transcripts
ENSBTAT00000012306 ENSBTAP00000012306
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004623 phospholipase A2 activity
GO:0005509 calcium ion binding
Biological Process
GO:0016042 lipid catabolic process
GO:0042632 cholesterol homeostasis
GO:0070328 triglyceride homeostasis
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000138308
View Gene Order
ENSMUSG00000009646
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00592
alpha-Linolenic acid metabolism pathway
hsa00590
Arachidonic acid metabolism pathway
hsa00564
Glycerophospholipid metabolism pathway
hsa00591
Linoleic acid metabolism pathway
hsa00565
Ether lipid metabolism pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa04975
Fat digestion and absorption pathway
hsa04972
Pancreatic secretion pathway
mmu00564
Glycerophospholipid metabolism pathway
mmu00590
Arachidonic acid metabolism pathway
mmu00565
Ether lipid metabolism pathway
mmu00591
Linoleic acid metabolism pathway
mmu00592
alpha-Linolenic acid metabolism pathway
mmu04270
Vascular smooth muscle contraction pathway
mmu04972
Pancreatic secretion pathway
mmu04975
Fat digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BFK0
UniProt Splice Variant
Entrez Gene 100337447
UniGene
RefSeq XM_002698874 XM_003584193 XM_005199532 XM_005226496
HUGO HGNC:18555
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02061880
GenPept
RNA Seq Atlas 100337447

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca