InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: NR1I3

Summary

InnateDB Gene

IDBG-630121.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NR1I3

Gene Name

nuclear receptor subfamily 1 group I member 3

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000009215

Encoded Proteins

IDBP-681561

nuclear receptor subfamily 1 group I member 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143257:
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:8290360-8295271

Strand

Forward strand

Band

Transcripts

ENSBTAT00000012145

ENSBTAP00000012145

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0043401	steroid hormone mediated signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000143257

View Gene Order

ENSMUSG00000005677

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_234105

Nuclear Receptor transcription pathway pathway

REACT_233572

Gene Expression pathway

REACT_206529

Generic Transcription Pathway pathway

KEGG

INOH

PID NCI

reg_gr_pathway

Glucocorticoid receptor regulatory network

Cross-References

SwissProt

TrEMBL

Q2KIF4 Q5S1S0

UniProt Splice Variant

Entrez Gene

493711

UniGene

RefSeq

NM_001079768 XM_005203462

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AY789649 BC112658 DAAA02006955

GenPept

AAI12659 AAV63559

RNA Seq Atlas

493711