InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.26387

Summary

InnateDB Gene

IDBG-630155.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.26387

Gene Name

glutamate receptor, ionotropic kainate 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000034854

Encoded Proteins

IDBP-681625

glutamate receptor, ionotropic kainate 1

IDBP-681641

glutamate receptor, ionotropic kainate 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171189:
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:5745203-5915273

Strand

Forward strand

Band

Transcripts

ENSBTAT00000026819	ENSBTAP00000026819
ENSBTAT00000026817	ENSBTAP00000026817

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004970	ionotropic glutamate receptor activity
GO:0005215	transporter activity
GO:0005216	ion channel activity
GO:0005234	extracellular-glutamate-gated ion channel activity
GO:0005515	protein binding
GO:0015277	kainate selective glutamate receptor activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0014054	positive regulation of gamma-aminobutyric acid secretion
GO:0030534	adult behavior
GO:0032230	positive regulation of synaptic transmission, GABAergic
GO:0034220	ion transmembrane transport
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035249	synaptic transmission, glutamatergic
GO:0042391	regulation of membrane potential
GO:0048266	behavioral response to pain
GO:0051899	membrane depolarization
GO:0051967	negative regulation of synaptic transmission, glutamatergic
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0060080	regulation of inhibitory postsynaptic membrane potential

Cellular Component

GO:0005886	plasma membrane
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0032983	kainate selective glutamate receptor complex
GO:0042734	presynaptic membrane
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0097481	neuronal postsynaptic density