Version 5.4
Bos taurus Gene: IL6
Summary
InnateDB Gene IDBG-630280.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL6
Gene Name Interleukin-6
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000014921
Encoded Proteins
IDBP-681725
Interleukin-6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 4:31578311-31582667
Strand Forward strand
Band
Transcripts
ENSBTAT00000019865 ENSBTAP00000019865
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005138 interleukin-6 receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0001781 neutrophil apoptotic process
GO:0002675 positive regulation of acute inflammatory response
GO:0006953 acute-phase response
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0008284 positive regulation of cell proliferation
GO:0009611 response to wounding
GO:0010574 regulation of vascular endothelial growth factor production
GO:0019221 cytokine-mediated signaling pathway
GO:0031018 endocrine pancreas development
GO:0031175 neuron projection development
GO:0032494 response to peptidoglycan
GO:0032722 positive regulation of chemokine production
GO:0032755 positive regulation of interleukin-6 production
GO:0032966 negative regulation of collagen biosynthetic process
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0042102 positive regulation of T cell proliferation
GO:0042110 T cell activation
GO:0042127 regulation of cell proliferation
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042832 defense response to protozoan
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043410 positive regulation of MAPK cascade
GO:0045079 negative regulation of chemokine biosynthetic process
GO:0045630 positive regulation of T-helper 2 cell differentiation
GO:0045727 positive regulation of translation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046427 positive regulation of JAK-STAT cascade
GO:0046716 muscle cell cellular homeostasis
GO:0046888 negative regulation of hormone secretion
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0050871 positive regulation of B cell activation
GO:0051024 positive regulation of immunoglobulin secretion
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051384 response to glucocorticoid
GO:0051607 defense response to virus
GO:0060445 branching involved in salivary gland morphogenesis
GO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis
GO:0070091 glucagon secretion
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070301 cellular response to hydrogen peroxide
GO:0071222 cellular response to lipopolysaccharide
GO:0072540 T-helper 17 cell lineage commitment
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005896 interleukin-6 receptor complex
GO:0009897 external side of plasma membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_217956
DAP12 interactions pathway
REACT_206974
Insulin receptor signalling cascade pathway
REACT_208036
Signaling by EGFR pathway
REACT_227719
ARMS-mediated activation pathway
REACT_218381
Signalling to ERKs pathway
REACT_218237
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_206968
GRB2 events in ERBB2 signaling pathway
REACT_210286
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_205036
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_227943
SOS-mediated signalling pathway
REACT_225366
IRS-related events triggered by IGF1R pathway
REACT_224703
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_217282
NCAM signaling for neurite out-growth pathway
REACT_207313
ERK activation pathway
REACT_205369
Signaling by GPCR pathway
REACT_204365
Signaling by PDGF pathway
REACT_205566
Activated TLR4 signalling pathway
REACT_222278
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_224546
MyD88-independent cascade pathway
REACT_217364
Signaling by Leptin pathway
REACT_216183
Signaling by ERBB4 pathway
REACT_208840
SHC-mediated signalling pathway
REACT_217035
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_227345
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_210224
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_211997
SHC1 events in ERBB2 signaling pathway
REACT_202837
Signaling by FGFR pathway
REACT_226349
Interleukin-2 signaling pathway
REACT_213612
Cytokine Signaling in Immune system pathway
REACT_211156
Prolonged ERK activation events pathway
REACT_206069
Cellular responses to stress pathway
REACT_208835
IRS-related events pathway
REACT_246299
VEGFA-VEGFR2 Pathway pathway
REACT_218532
SHC1 events in EGFR signaling pathway
REACT_213138
Immune System pathway
REACT_224404
IRS-mediated signalling pathway
REACT_205176
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_227036
MAP kinase activation in TLR cascade pathway
REACT_216354
IGF1R signaling cascade pathway
REACT_229952
VEGFR2 mediated cell proliferation pathway
REACT_225676
SHC-related events pathway
REACT_218958
Signaling by ERBB2 pathway
REACT_219220
Toll-Like Receptors Cascades pathway
REACT_214353
Signal Transduction pathway
REACT_215025
Cellular Senescence pathway
REACT_219546
Signaling by Insulin receptor pathway
REACT_221368
Signaling by EGFR in Cancer pathway
REACT_214419
Signalling to RAS pathway
REACT_203968
RAF/MAP kinase cascade pathway
REACT_223442
SHC1 events in ERBB4 signaling pathway
REACT_203140
Axon guidance pathway
REACT_223848
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_225659
Signalling to p38 via RIT and RIN pathway
REACT_201972
SHC-related events triggered by IGF1R pathway
REACT_225653
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_212815
Interleukin-6 signaling pathway
REACT_207949
NGF signalling via TRKA from the plasma membrane pathway
REACT_218091
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_227498
ERK1 activation pathway
REACT_206613
Downstream signaling of activated FGFR pathway
REACT_207066
Signalling by NGF pathway
REACT_226693
Signaling by VEGF pathway
REACT_204150
GRB2 events in EGFR signaling pathway
REACT_216676
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_219586
MyD88 dependent cascade initiated on endosome pathway
REACT_212750
Downstream signal transduction pathway
REACT_204114
Signaling by SCF-KIT pathway
REACT_216714
Innate Immune System pathway
REACT_203215
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_202074
FCERI mediated MAPK activation pathway
REACT_217712
Frs2-mediated activation pathway
REACT_203938
FRS2-mediated cascade pathway
REACT_206833
Signaling by Interleukins pathway
REACT_214988
DAP12 signaling pathway
REACT_207087
Disease pathway
REACT_203736
Signaling by FGFR in disease pathway
REACT_211704
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_225357
Fc epsilon receptor (FCERI) signaling pathway
REACT_217527
MyD88 cascade initiated on plasma membrane pathway
REACT_220844
Developmental Biology pathway
REACT_210032
ERK2 activation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P26892
TrEMBL
UniProt Splice Variant
Entrez Gene 280826
UniGene
RefSeq NM_173923
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC123577 EU276071 X57317
GenPept AAI23578 ABX72069 CAA40572
RNA Seq Atlas 280826

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca