Version 5.4
Bos taurus Protein: IL6
Summary
InnateDB Protein IDBP-681725.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL6
Protein Name Interleukin-6
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000019865
InnateDB Gene IDBG-630280 (IL6)
Protein Structure
UniProt Annotation
Function Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation (By similarity). {ECO:0000250}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005138 interleukin-6 receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0001781 neutrophil apoptotic process
GO:0002675 positive regulation of acute inflammatory response
GO:0006953 acute-phase response
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0008284 positive regulation of cell proliferation
GO:0009611 response to wounding
GO:0010574 regulation of vascular endothelial growth factor production
GO:0019221 cytokine-mediated signaling pathway
GO:0031018 endocrine pancreas development
GO:0031175 neuron projection development
GO:0032494 response to peptidoglycan
GO:0032722 positive regulation of chemokine production
GO:0032755 positive regulation of interleukin-6 production
GO:0032966 negative regulation of collagen biosynthetic process
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0042102 positive regulation of T cell proliferation
GO:0042110 T cell activation
GO:0042127 regulation of cell proliferation
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042832 defense response to protozoan
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043410 positive regulation of MAPK cascade
GO:0045079 negative regulation of chemokine biosynthetic process
GO:0045630 positive regulation of T-helper 2 cell differentiation
GO:0045727 positive regulation of translation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046427 positive regulation of JAK-STAT cascade
GO:0046716 muscle cell cellular homeostasis
GO:0046888 negative regulation of hormone secretion
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0050871 positive regulation of B cell activation
GO:0051024 positive regulation of immunoglobulin secretion
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051384 response to glucocorticoid
GO:0051607 defense response to virus
GO:0060445 branching involved in salivary gland morphogenesis
GO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis
GO:0070091 glucagon secretion
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070301 cellular response to hydrogen peroxide
GO:0071222 cellular response to lipopolysaccharide
GO:0072540 T-helper 17 cell lineage commitment
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005896 interleukin-6 receptor complex
GO:0009897 external side of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR003573 Interleukin-6/Interleukin-23/GCSF/MGF
IPR003574 Interleukin-6
IPR009079 Four-helical cytokine-like, core
PFAM PF00489
PRINTS PR00433
PR00434
PIRSF PIRSF001935
SMART SM00126
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P26892
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 280826
UniGene
RefSeq NP_776348
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC123577 EU276071 X57317
GenPept AAI23578 ABX72069 CAA40572

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca