Version 5.4
Bos taurus Gene: BT.99652
Summary
InnateDB Gene IDBG-630320.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.99652
Gene Name transmembrane glycoprotein NMB precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000000604
Encoded Proteins
IDBP-681771
transmembrane glycoprotein NMB
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136235:
The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:32010892-32037150
Strand Forward strand
Band
Transcripts
ENSBTAT00000000796 ENSBTAP00000000796
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
GO:0008201 heparin binding
Biological Process
GO:0007155 cell adhesion
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000136235
View Gene Order
ENSMUSG00000029816
View Gene Order
Cross-References
SwissProt
TrEMBL F6PRW9
UniProt Splice Variant
Entrez Gene 509600
UniGene Bt.9807 Bt.99652
RefSeq NM_001038065 XM_005205255
HUGO HGNC:4462
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02010222
GenPept
RNA Seq Atlas 509600

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca