Version 5.4
Mus musculus Gene: Gpnmb
Summary
InnateDB Gene IDBG-146080.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gpnmb
Gene Name glycoprotein (transmembrane) nmb
Synonyms DC-HIL; Dchil; ipd
Species Mus musculus
Ensembl Gene ENSMUSG00000029816
Encoded Proteins
IDBP-146082
glycoprotein (transmembrane) nmb
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136235:
The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:49036518-49058182
Strand Forward strand
Band B2.3
Transcripts
ENSMUST00000031840 ENSMUSP00000031840
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
GO:0008201 heparin binding
Biological Process
GO:0001649 osteoblast differentiation
GO:0007155 cell adhesion
GO:0030282 bone mineralization
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0012505 endomembrane system
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030659 cytoplasmic vesicle membrane
GO:0042470 melanosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000136235
View Gene Order
ENSBTAG00000000604
Not yet available
Cross-References
SwissProt Q99P91
TrEMBL Q3UE75
UniProt Splice Variant
Entrez Gene 93695
UniGene Mm.302602
RefSeq NM_053110
OMIM
CCDS CCDS20122
HPRD
IMGT
MGI ID MGI:1934765
MGI Symbol Gpnmb
EMBL AF322054 AJ251685 AK044764 AK076347 AK149700 AK150739 AK154617 AK170506 AK171441 AK171465 AK171474 AK171517 BC026375
GenPept AAH26375 AAK14240 BAC32074 BAC36306 BAE29036 BAE29813 BAE32716 BAE41844 BAE42454 BAE42471 BAE42479 BAE42501 CAB65272
RNA Seq Atlas 93695

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca