Version 5.4
Bos taurus Gene: LHX1
Summary
InnateDB Gene IDBG-630361.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LHX1
Gene Name LIM/homeobox protein Lhx1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000033562
Encoded Proteins
IDBP-681812
LIM homeobox protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog null:
This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor important for the development of the renal and urogenital systems. This gene is a candidate for Mayer-Rokitansky-Kuster-Hauser syndrome, a disorder characterized by anomalies in the female genital tract. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:13611604-13617403
Strand Forward strand
Band
Transcripts
ENSBTAT00000047689 ENSBTAP00000044870
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0001655 urogenital system development
GO:0001656 metanephros development
GO:0001657 ureteric bud development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001702 gastrulation with mouth forming second
GO:0001705 ectoderm formation
GO:0001706 endoderm formation
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007267 cell-cell signaling
GO:0007389 pattern specification process
GO:0008045 motor neuron axon guidance
GO:0009653 anatomical structure morphogenesis
GO:0009791 post-embryonic development
GO:0009880 embryonic pattern specification
GO:0009948 anterior/posterior axis specification
GO:0009952 anterior/posterior pattern specification
GO:0009953 dorsal/ventral pattern formation
GO:0010468 regulation of gene expression
GO:0010842 retina layer formation
GO:0021510 spinal cord development
GO:0021517 ventral spinal cord development
GO:0021527 spinal cord association neuron differentiation
GO:0021537 telencephalon development
GO:0021549 cerebellum development
GO:0021702 cerebellar Purkinje cell differentiation
GO:0021871 forebrain regionalization
GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation
GO:0032525 somite rostral/caudal axis specification
GO:0035846 oviduct epithelium development
GO:0035847 uterine epithelium development
GO:0035849 nephric duct elongation
GO:0035852 horizontal cell localization
GO:0040019 positive regulation of embryonic development
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0048703 embryonic viscerocranium morphogenesis
GO:0048793 pronephros development
GO:0060041 retina development in camera-type eye
GO:0060059 embryonic retina morphogenesis in camera-type eye
GO:0060065 uterus development
GO:0060066 oviduct development
GO:0060067 cervix development
GO:0060068 vagina development
GO:0060322 head development
GO:0060429 epithelium development
GO:0061205 paramesonephric duct development
GO:0072001 renal system development
GO:0072049 comma-shaped body morphogenesis
GO:0072050 S-shaped body morphogenesis
GO:0072077 renal vesicle morphogenesis
GO:0072178 nephric duct morphogenesis
GO:0072283 metanephric renal vesicle morphogenesis
GO:0072284 metanephric S-shaped body morphogenesis
GO:0090009 primitive streak formation
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:0097477 lateral motor column neuron migration
GO:2000543 positive regulation of gastrulation
GO:2000744 positive regulation of anterior head development
GO:2000768 positive regulation of nephron tubule epithelial cell differentiation
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
null
View Gene Order
ENSMUSG00000018698
View Gene Order
Cross-References
SwissProt
TrEMBL A7Z015
UniProt Splice Variant
Entrez Gene 786041
UniGene Bt.104440 Bt.62356
RefSeq NM_001105447 XM_003583534
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC153212 DAAA02048434
GenPept AAI53213
RNA Seq Atlas 616699 786041

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca