Version 5.4
Mus musculus Gene: Lhx1
Summary
InnateDB Gene IDBG-206273.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lhx1
Gene Name LIM homeobox protein 1
Synonyms Lim1
Species Mus musculus
Ensembl Gene ENSMUSG00000018698
Encoded Proteins
IDBP-206275
LIM homeobox protein 1
IDBP-206277
LIM homeobox protein 1
IDBP-787888
LIM homeobox protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog null:
This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor important for the development of the renal and urogenital systems. This gene is a candidate for Mayer-Rokitansky-Kuster-Hauser syndrome, a disorder characterized by anomalies in the female genital tract. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:84518284-84525535
Strand Reverse strand
Band C
Transcripts
ENSMUST00000018842 ENSMUSP00000018842
ENSMUST00000092827 ENSMUSP00000090503
ENSMUST00000176503
ENSMUST00000184646 ENSMUSP00000138899
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001655 urogenital system development
GO:0001656 metanephros development
GO:0001657 ureteric bud development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001702 gastrulation with mouth forming second
GO:0001705 ectoderm formation
GO:0001706 endoderm formation
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007267 cell-cell signaling
GO:0007389 pattern specification process
GO:0008045 motor neuron axon guidance
GO:0009653 anatomical structure morphogenesis
GO:0009791 post-embryonic development
GO:0009880 embryonic pattern specification
GO:0009948 anterior/posterior axis specification
GO:0009952 anterior/posterior pattern specification
GO:0009953 dorsal/ventral pattern formation
GO:0010468 regulation of gene expression
GO:0010842 retina layer formation
GO:0021510 spinal cord development
GO:0021517 ventral spinal cord development
GO:0021527 spinal cord association neuron differentiation
GO:0021537 telencephalon development
GO:0021549 cerebellum development
GO:0021702 cerebellar Purkinje cell differentiation
GO:0021871 forebrain regionalization
GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation
GO:0032525 somite rostral/caudal axis specification
GO:0035502 metanephric part of ureteric bud development
GO:0035846 oviduct epithelium development
GO:0035847 uterine epithelium development
GO:0035849 nephric duct elongation
GO:0035852 horizontal cell localization
GO:0040019 positive regulation of embryonic development
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0048703 embryonic viscerocranium morphogenesis
GO:0048793 pronephros development
GO:0060041 retina development in camera-type eye
GO:0060059 embryonic retina morphogenesis in camera-type eye
GO:0060065 uterus development
GO:0060066 oviduct development
GO:0060067 cervix development
GO:0060068 vagina development
GO:0060322 head development
GO:0060429 epithelium development
GO:0061205 paramesonephric duct development
GO:0072001 renal system development
GO:0072049 comma-shaped body morphogenesis
GO:0072050 S-shaped body morphogenesis
GO:0072077 renal vesicle morphogenesis
GO:0072164 mesonephric tubule development
GO:0072177 mesonephric duct development
GO:0072178 nephric duct morphogenesis
GO:0072224 metanephric glomerulus development
GO:0072278 metanephric comma-shaped body morphogenesis
GO:0072283 metanephric renal vesicle morphogenesis
GO:0072284 metanephric S-shaped body morphogenesis
GO:0090009 primitive streak formation
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:0097477 lateral motor column neuron migration
GO:2000543 positive regulation of gastrulation
GO:2000744 positive regulation of anterior head development
GO:2000768 positive regulation of nephron tubule epithelial cell differentiation
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
null
View Gene Order
ENSBTAG00000033562
Not yet available
Cross-References
SwissProt P63006
TrEMBL Q569N5 Q8BNR0 Q8CCU9
UniProt Splice Variant
Entrez Gene 16869
UniGene Mm.468359 Mm.4965
RefSeq NM_008498
OMIM
CCDS CCDS25187
HPRD
IMGT
MGI ID MGI:99783
MGI Symbol Lhx1
EMBL AF039705 AF039706 AK032067 AK080848 BC092374 CH466556 S68107 Z27410
GenPept AAC60669 AAD02169 AAH92374 BAC27679 BAC38043 CAA81797 EDL15738
RNA Seq Atlas 16869

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca