Version 5.4
| Bos taurus Gene: BT.88312 | |||||||||||||||||||||
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| Summary | |||||||||||||||||||||
| InnateDB Gene | IDBG-630401.3 | ||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||
| Gene Symbol | BT.88312 | ||||||||||||||||||||
| Gene Name | acetyl-CoA carboxylase 1 | ||||||||||||||||||||
| Synonyms | ACC1; ACCA | ||||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||||
| Ensembl Gene | ENSBTAG00000017567 | ||||||||||||||||||||
| Encoded Proteins |
acetyl-CoA carboxylase 1
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| Protein Structure | |||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog null:
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||
| Genomic Location | Chromosome 19:13752492-13996058 | ||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||
| Band | |||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||
| NETPATH |
Leptin pathway
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| REACTOME |
Activation of gene expression by SREBF (SREBP) pathway
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
Import of palmitoyl-CoA into the mitochondrial matrix pathway
Fatty Acyl-CoA Biosynthesis pathway
Triglyceride Biosynthesis pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
ChREBP activates metabolic gene expression pathway
Integration of energy metabolism pathway
Biotin transport and metabolism pathway
Metabolism of lipids and lipoproteins pathway
Defective HLCS causes multiple carboxylase deficiency pathway
Defective MUT causes methylmalonic aciduria mut type pathway
Defective MMAA causes methylmalonic aciduria type cblA pathway
Defective TCN2 causes hereditary megaloblastic anemia pathway
Metabolism of water-soluble vitamins and cofactors pathway
Defective AMN causes hereditary megaloblastic anemia 1 pathway
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG pathway
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF pathway
Defective CD320 causes methylmalonic aciduria pathway
Defects in cobalamin (B12) metabolism pathway
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC pathway
Defects in biotin (Btn) metabolism pathway
Defective BTD causes biotidinase deficiency pathway
Defective GIF causes intrinsic factor deficiency pathway
Defects in vitamin and cofactor metabolism pathway
Defective CUBN causes hereditary megaloblastic anemia 1 pathway
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD pathway
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE pathway
Metabolism pathway
Defective MMAB causes methylmalonic aciduria type cblB pathway
Disease pathway
Metabolism of vitamins and cofactors pathway
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF pathway
Disease pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Integration of energy metabolism pathway
Activation of gene expression by SREBF (SREBP) pathway
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
ChREBP activates metabolic gene expression pathway
Fatty Acyl-CoA Biosynthesis pathway
Triglyceride Biosynthesis pathway
Defective AMN causes hereditary megaloblastic anemia 1 pathway
Defective GIF causes intrinsic factor deficiency pathway
Defective MMAA causes methylmalonic aciduria type cblA pathway
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC pathway
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD pathway
Defective CD320 causes methylmalonic aciduria pathway
Defective MUT causes methylmalonic aciduria mut type pathway
Defects in biotin (Btn) metabolism pathway
Defective BTD causes biotidinase deficiency pathway
Defective MMAB causes methylmalonic aciduria type cblB pathway
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG pathway
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE pathway
Defective CUBN causes hereditary megaloblastic anemia 1 pathway
Metabolism of vitamins and cofactors pathway
Import of palmitoyl-CoA into the mitochondrial matrix pathway
Metabolism of water-soluble vitamins and cofactors pathway
Biotin transport and metabolism pathway
Defects in vitamin and cofactor metabolism pathway
Defects in cobalamin (B12) metabolism pathway
Defective TCN2 causes hereditary megaloblastic anemia pathway
Defective HLCS causes multiple carboxylase deficiency pathway
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| KEGG |
Fatty acid biosynthesis pathway
Pyruvate metabolism pathway
Propanoate metabolism pathway
Insulin signaling pathway pathway
Insulin signaling pathway pathway
Propanoate metabolism pathway
Fatty acid biosynthesis pathway
Pyruvate metabolism pathway
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| INOH | |||||||||||||||||||||
| PID NCI | |||||||||||||||||||||
| Cross-References | |||||||||||||||||||||
| SwissProt | |||||||||||||||||||||
| TrEMBL | E1BGH6 | ||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||
| Entrez Gene | 281590 | ||||||||||||||||||||
| UniGene | Bt.2804 Bt.88312 | ||||||||||||||||||||
| RefSeq | NM_174224 XM_005219975 XM_005219976 XM_005219977 XM_005219978 | ||||||||||||||||||||
| HUGO | HGNC:84 | ||||||||||||||||||||
| OMIM | |||||||||||||||||||||
| CCDS | |||||||||||||||||||||
| HPRD | |||||||||||||||||||||
| IMGT | |||||||||||||||||||||
| EMBL | DAAA02048435 DAAA02048436 DAAA02048437 DAAA02048438 DAAA02048439 DAAA02048440 | ||||||||||||||||||||
| GenPept | |||||||||||||||||||||
| RNA Seq Atlas | 281590 | ||||||||||||||||||||