Version 5.4
Mus musculus Gene: Acaca
Summary
InnateDB Gene IDBG-206042.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Acaca
Gene Name acetyl-Coenzyme A carboxylase alpha
Synonyms A530025K05Rik; Acac; Acc1; Gm738
Species Mus musculus
Ensembl Gene ENSMUSG00000020532
Encoded Proteins
IDBP-206046
acetyl-Coenzyme A carboxylase alpha
IDBP-206050
acetyl-Coenzyme A carboxylase alpha
IDBP-534989
acetyl-Coenzyme A carboxylase alpha
IDBP-541786
acetyl-Coenzyme A carboxylase alpha
IDBP-535827
acetyl-Coenzyme A carboxylase alpha
IDBP-533642
acetyl-Coenzyme A carboxylase alpha
IDBP-787874
acetyl-Coenzyme A carboxylase alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog null:
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:84129672-84401651
Strand Forward strand
Band C
Transcripts
ENSMUST00000103201 ENSMUSP00000099490
ENSMUST00000020843 ENSMUSP00000020843
ENSMUST00000133811 ENSMUSP00000116174
ENSMUST00000136463 ENSMUSP00000116295
ENSMUST00000137500 ENSMUSP00000121274
ENSMUST00000130012 ENSMUSP00000117972
ENSMUST00000184534
ENSMUST00000183548
ENSMUST00000183887 ENSMUSP00000139378
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 35 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003989 acetyl-CoA carboxylase activity
GO:0004075 biotin carboxylase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008716 D-alanine-D-alanine ligase activity
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0001894 tissue homeostasis
GO:0006084 acetyl-CoA metabolic process
GO:0006629 lipid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0008152 metabolic process
GO:0044268 multicellular organismal protein metabolic process
GO:0051289 protein homotetramerization
GO:0055088 lipid homeostasis
GO:2001295 malonyl-CoA biosynthetic process
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
null
View Gene Order
ENSBTAG00000017567
Not yet available
Pathways
NETPATH
REACTOME
REACT_189088
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF pathway
REACT_189085
Disease pathway
REACT_256522
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_217323
Integration of energy metabolism pathway
REACT_198969
Activation of gene expression by SREBF (SREBP) pathway
REACT_198968
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_231395
ChREBP activates metabolic gene expression pathway
REACT_255695
Fatty Acyl-CoA Biosynthesis pathway
REACT_237947
Triglyceride Biosynthesis pathway
REACT_189089
Defective AMN causes hereditary megaloblastic anemia 1 pathway
REACT_189086
Defective GIF causes intrinsic factor deficiency pathway
REACT_189075
Defective MMAA causes methylmalonic aciduria type cblA pathway
REACT_189076
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC pathway
REACT_189078
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD pathway
REACT_189098
Defective CD320 causes methylmalonic aciduria pathway
REACT_189097
Defective MUT causes methylmalonic aciduria mut type pathway
REACT_189096
Defects in biotin (Btn) metabolism pathway
REACT_189095
Defective BTD causes biotidinase deficiency pathway
REACT_189093
Defective MMAB causes methylmalonic aciduria type cblB pathway
REACT_189092
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG pathway
REACT_189091
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE pathway
REACT_189090
Defective CUBN causes hereditary megaloblastic anemia 1 pathway
REACT_254651
Metabolism of vitamins and cofactors pathway
REACT_257268
Import of palmitoyl-CoA into the mitochondrial matrix pathway
REACT_238663
Metabolism of water-soluble vitamins and cofactors pathway
REACT_206176
Biotin transport and metabolism pathway
REACT_189110
Defects in vitamin and cofactor metabolism pathway
REACT_189116
Defects in cobalamin (B12) metabolism pathway
REACT_189114
Defective TCN2 causes hereditary megaloblastic anemia pathway
REACT_189100
Defective HLCS causes multiple carboxylase deficiency pathway
KEGG
mmu04910
Insulin signaling pathway pathway
mmu00640
Propanoate metabolism pathway
mmu00061
Fatty acid biosynthesis pathway
mmu00620
Pyruvate metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_22
Leptin pathway
REACTOME
REACT_147904
Activation of gene expression by SREBF (SREBP) pathway
REACT_147797
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_11082
Import of palmitoyl-CoA into the mitochondrial matrix pathway
REACT_1319
Fatty Acyl-CoA Biosynthesis pathway
REACT_1190
Triglyceride Biosynthesis pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_2122
ChREBP activates metabolic gene expression pathway
REACT_1505
Integration of energy metabolism pathway
REACT_11153
Biotin transport and metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_169312
Defective HLCS causes multiple carboxylase deficiency pathway
REACT_169313
Defective MUT causes methylmalonic aciduria mut type pathway
REACT_169316
Defective MMAA causes methylmalonic aciduria type cblA pathway
REACT_169120
Defective TCN2 causes hereditary megaloblastic anemia pathway
REACT_11238
Metabolism of water-soluble vitamins and cofactors pathway
REACT_169280
Defective AMN causes hereditary megaloblastic anemia 1 pathway
REACT_169149
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG pathway
REACT_169363
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF pathway
REACT_169178
Defective CD320 causes methylmalonic aciduria pathway
REACT_169429
Defects in cobalamin (B12) metabolism pathway
REACT_169169
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC pathway
REACT_169238
Defects in biotin (Btn) metabolism pathway
REACT_169403
Defective BTD causes biotidinase deficiency pathway
REACT_169415
Defective GIF causes intrinsic factor deficiency pathway
REACT_169385
Defects in vitamin and cofactor metabolism pathway
REACT_169132
Defective CUBN causes hereditary megaloblastic anemia 1 pathway
REACT_169256
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD pathway
REACT_169439
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE pathway
REACT_111217
Metabolism pathway
REACT_169318
Defective MMAB causes methylmalonic aciduria type cblB pathway
REACT_116125
Disease pathway
REACT_11193
Metabolism of vitamins and cofactors pathway
KEGG
hsa00061
Fatty acid biosynthesis pathway
hsa00620
Pyruvate metabolism pathway
hsa00640
Propanoate metabolism pathway
hsa04910
Insulin signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q5SWU9
TrEMBL Q9ESZ5 V9GWR9 V9GWS0 V9GWS1
UniProt Splice Variant
Entrez Gene 107476
UniGene Mm.31374
RefSeq NM_133360 XM_006544737 XM_006531951 XM_006531953 XM_006531954 XM_006531955 XM_006531956 XM_006531957 XM_006531958
OMIM
CCDS CCDS25185
HPRD
IMGT
MGI ID MGI:108451
MGI Symbol Acaca
EMBL AF289714 AF374167 AF374168 AF374169 AF374170 AJ619664 AJ619665 AL596252 AL596447 AY451393 BC056500
GenPept AAG01858 AAH56500 AAK57389 AAK57390 AAK57391 AAK57392 AAS13685 CAF02251 CAF02252 CAI24019 CAI25271 CAI25272 CAI25273 CAI25274 CAM21560
RNA Seq Atlas 102641888 107476

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca