InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PRLR

Summary

InnateDB Gene

IDBG-630451.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRLR

Gene Name

prolactin receptor long form precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000025035

Encoded Proteins

IDBP-681934

prolactin receptor long form

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113494:
This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:39073246-39137480

Strand

Forward strand

Band

Transcripts

ENSBTAT00000014437

ENSBTAP00000014437

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004896	cytokine receptor activity
GO:0004925	prolactin receptor activity
GO:0005515	protein binding
GO:0017046	peptide hormone binding

Biological Process

GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity
GO:0007259	JAK-STAT cascade
GO:0007595	lactation
GO:0019221	cytokine-mediated signaling pathway
GO:0030155	regulation of cell adhesion
GO:0030856	regulation of epithelial cell differentiation
GO:0038161	prolactin signaling pathway
GO:0060644	mammary gland epithelial cell differentiation
GO:0060736	prostate gland growth
GO:0060749	mammary gland alveolus development
GO:0061180	mammary gland epithelium development