Version 5.4
Homo sapiens Gene: PRLR
Summary
InnateDB Gene IDBG-15793.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRLR
Gene Name prolactin receptor
Synonyms HPRL; hPRLrI; MFAB
Species Homo sapiens
Ensembl Gene ENSG00000113494
Encoded Proteins
IDBP-15795
prolactin receptor
IDBP-15797
prolactin receptor
IDBP-15805
prolactin receptor
IDBP-235452
prolactin receptor
IDBP-479938
prolactin receptor
IDBP-482798
prolactin receptor
IDBP-482633
prolactin receptor
IDBP-481248
prolactin receptor
IDBP-484169
prolactin receptor
IDBP-475411
prolactin receptor
IDBP-474079
prolactin receptor
IDBP-483629
prolactin receptor
IDBP-476570
prolactin receptor
IDBP-474944
prolactin receptor
IDBP-584435
prolactin receptor
IDBP-806270
prolactin receptor
IDBP-806274
prolactin receptor
IDBP-806285
prolactin receptor
IDBP-806289
prolactin receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:35048756-35230589
Strand Reverse strand
Band p13.2
Transcripts
ENST00000231423 ENSP00000231423
ENST00000348262 ENSP00000311613
ENST00000310101 ENSP00000309008
ENST00000397391 ENSP00000380546
ENST00000513753 ENSP00000424841
ENST00000514088 ENSP00000422935
ENST00000509140 ENSP00000425300
ENST00000508107 ENSP00000427236
ENST00000511486 ENSP00000422556
ENST00000509934
ENST00000514206 ENSP00000423493
ENST00000509839 ENSP00000427060
ENST00000503330 ENSP00000422385
ENST00000504500 ENSP00000422867
ENST00000515839 ENSP00000421864
ENST00000542609 ENSP00000441813
ENST00000618625 ENSP00000479077
ENST00000618457 ENSP00000482954
ENST00000619676 ENSP00000484768
ENST00000620785 ENSP00000482689
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 33 [view]
Protein-Protein 30 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004896 cytokine receptor activity
GO:0004925 prolactin receptor activity
GO:0005515 protein binding
GO:0017046 peptide hormone binding
GO:0042803 protein homodimerization activity
GO:0042978 ornithine decarboxylase activator activity
GO:0046872 metal ion binding
Biological Process
GO:0006694 steroid biosynthetic process
GO:0007166 cell surface receptor signaling pathway
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity
GO:0007259 JAK-STAT cascade
GO:0007566 embryo implantation
GO:0007595 lactation
GO:0019221 cytokine-mediated signaling pathway
GO:0030155 regulation of cell adhesion
GO:0030856 regulation of epithelial cell differentiation
GO:0038161 prolactin signaling pathway
GO:0042110 T cell activation
GO:0042977 activation of JAK2 kinase activity
GO:0043066 negative regulation of apoptotic process
GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway
GO:0060644 mammary gland epithelial cell differentiation
GO:0060736 prostate gland growth
GO:0060749 mammary gland alveolus development
GO:0061180 mammary gland epithelium development
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031904 endosome lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005268
View Gene Order
ENSBTAG00000025035
Not yet available
Pathways
NETPATH
NetPath_56
Prolactin pathway
REACTOME
REACT_111133
Growth hormone receptor signaling pathway
REACT_115697
Prolactin receptor signaling pathway
REACT_116022
Nuclear signaling by ERBB4 pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_111102
Signal Transduction pathway
REACT_6900
Immune System pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
PID NCI
erbb4_pathway
ErbB4 signaling events
ptp1bpathway
Signaling events mediated by PTP1B
Cross-References
SwissProt
TrEMBL D6R9P5 D6R9V7 D6RAN9 D6RC67 D6RD41 Q16264
UniProt Splice Variant
Entrez Gene 5618
UniGene
RefSeq NM_001204315 NM_000949 NM_001204314 NM_001204316 NM_001204317 NM_001204318 XM_006714484
HUGO HGNC:9446
OMIM 176761
CCDS CCDS56362 CCDS3909 CCDS56358 CCDS56359 CCDS56360 CCDS56361
HPRD
IMGT
EMBL AC010368 AC091851 S75672
GenPept AAB33685
RNA Seq Atlas 5618

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca