Bos taurus Gene: PTS | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Gene | IDBG-630501.3 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | PTS | ||||||||||||||
Gene Name | 6-pyruvoyl tetrahydrobiopterin synthase | ||||||||||||||
Synonyms | |||||||||||||||
Species | Bos taurus | ||||||||||||||
Ensembl Gene | ENSBTAG00000003770 | ||||||||||||||
Encoded Proteins |
6-pyruvoyl tetrahydrobiopterin synthase
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Protein Structure | |||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||
Entrez Gene | |||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000150787:
The enzyme encoded by this gene catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia. [provided by RefSeq, Oct 2008] |
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Gene Information | |||||||||||||||
Type | Protein coding | ||||||||||||||
Genomic Location | Chromosome 15:22912247-22920397 | ||||||||||||||
Strand | Forward strand | ||||||||||||||
Band | |||||||||||||||
Transcripts |
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Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||
NETPATH | |||||||||||||||
REACTOME |
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
eNOS activation and regulation pathway
Metabolism of nitric oxide pathway
Metabolism pathway
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
eNOS activation and regulation pathway
Metabolism pathway
Metabolism of nitric oxide pathway
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KEGG |
Folate biosynthesis pathway
Folate biosynthesis pathway
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INOH |
Folate metabolism pathway
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PID NCI | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | |||||||||||||||
TrEMBL | |||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | |||||||||||||||
UniGene | |||||||||||||||
RefSeq | NM_001113537 | ||||||||||||||
HUGO | |||||||||||||||
OMIM | |||||||||||||||
CCDS | |||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | |||||||||||||||
GenPept | |||||||||||||||
RNA Seq Atlas | |||||||||||||||