InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ALOX5AP

Summary

InnateDB Gene

IDBG-630519.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALOX5AP

Gene Name

Arachidonate 5-lipoxygenase-activating protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000013201

Encoded Proteins

IDBP-681978

Arachidonate 5-lipoxygenase-activating protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132965:
This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:30136998-30159808

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000017570

ENSBTAP00000017570

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008047	enzyme activator activity
GO:0047485	protein N-terminus binding
GO:0050544	arachidonic acid binding

Biological Process

GO:0002540	leukotriene production involved in inflammatory response
GO:0006691	leukotriene metabolic process
GO:0019370	leukotriene biosynthetic process
GO:0043085	positive regulation of catalytic activity
GO:0070207	protein homotrimerization
GO:0071277	cellular response to calcium ion

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane