InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ALOX5AP

Summary

InnateDB Gene

IDBG-21438.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALOX5AP

Gene Name

arachidonate 5-lipoxygenase-activating protein

Synonyms

FLAP

Species

Homo sapiens

Ensembl Gene

ENSG00000132965

Encoded Proteins

IDBP-21440

arachidonate 5-lipoxygenase-activating protein

IDBP-808875

arachidonate 5-lipoxygenase-activating protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:30713478-30764426

Strand

Forward strand

Band

q12.3

Transcripts

ENST00000380490	ENSP00000369858
ENST00000479597
ENST00000617770	ENSP00000479870

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	4 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004051	arachidonate 5-lipoxygenase activity
GO:0005515	protein binding
GO:0008047	enzyme activator activity
GO:0019899	enzyme binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0047485	protein N-terminus binding
GO:0050544	arachidonic acid binding

Biological Process

GO:0002540	leukotriene production involved in inflammatory response
GO:0002675	positive regulation of acute inflammatory response
GO:0006691	leukotriene metabolic process
GO:0019369	arachidonic acid metabolic process
GO:0019370	leukotriene biosynthetic process
GO:0019372	lipoxygenase pathway
GO:0043085	positive regulation of catalytic activity
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:0070207	protein homotrimerization
GO:0071277	cellular response to calcium ion
GO:2001300	lipoxin metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000060063

View Gene Order

ENSBTAG00000013201

Not yet available

Pathways

NETPATH

REACTOME

REACT_150209

Synthesis of 5-eicosatetraenoic acids pathway

REACT_150420

Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway

REACT_150320

Synthesis of Lipoxins (LX) pathway

REACT_147851

Arachidonic acid metabolism pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_111217

Metabolism pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

P20292

TrEMBL

UniProt Splice Variant

Entrez Gene

241

UniGene

RefSeq

NM_001629 NM_001204406

HUGO

HGNC:436

OMIM

603700

CCDS

CCDS9337 CCDS73558

HPRD

04742

IMGT

EMBL

AL512642 AY619687 BC018538 M60470 M63259 M63260 M63262 X52195

GenPept

AAA35845 AAH18538 AAT38104 CAA36441 CAH74084

RNA Seq Atlas

241