Version 5.4
Bos taurus Gene: CD48
Summary
InnateDB Gene IDBG-630526.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD48
Gene Name CD48 antigen precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000011238
Encoded Proteins
IDBP-681987
CD48 antigen
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 26564814
[Mus musculus] Invariant natural killer T cell activation induced by mast cells exposed to alpha-galactosylceramide is regulated by costimulatory molecules Cd48 and Tnfsf4.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117091:
This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:9022904-9053379
Strand Forward strand
Band
Transcripts
ENSBTAT00000014924 ENSBTAP00000014924
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0042110 T cell activation
Cellular Component
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000117091
View Gene Order
ENSMUSG00000015355
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_604
Hemostasis pathway
REACT_224553
Hemostasis pathway
REACT_225233
Cell surface interactions at the vascular wall pathway
KEGG
hsa04650
Natural killer cell mediated cytotoxicity pathway
mmu04650
Natural killer cell mediated cytotoxicity pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q2KHZ6
UniProt Splice Variant
Entrez Gene 508386
UniGene Bt.57922
RefSeq NM_001046002
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC112825 DAAA02006980
GenPept AAI12826
RNA Seq Atlas 508386

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca